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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1k22 MEL Prothrombin 3.4.21.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1k22 MELProthrombin 3.4.21.5 1.151
4bah MELProthrombin 3.4.21.5 1.127
4bak M67Prothrombin 3.4.21.5 1.120
4ban M6SProthrombin 3.4.21.5 1.119
4bam MM9Prothrombin 3.4.21.5 1.104
4bao MVFProthrombin 3.4.21.5 1.101
4baq M4ZProthrombin 3.4.21.5 1.061
2znk 31UProthrombin 3.4.21.5 0.940
2zg0 50UProthrombin 3.4.21.5 0.905
2zhq 27UProthrombin 3.4.21.5 0.902
2zi2 24UProthrombin 3.4.21.5 0.892
2zhf 49UProthrombin 3.4.21.5 0.881
2anm CDOProthrombin 3.4.21.5 0.875
2zfq 45UProthrombin 3.4.21.5 0.871
1riw OSCProthrombin 3.4.21.5 0.851
2ziq 26UProthrombin 3.4.21.5 0.845
2zfr 46UProthrombin 3.4.21.5 0.831
3utu 1TSProthrombin 3.4.21.5 0.828
1ypm RA4Prothrombin 3.4.21.5 0.827
2a2x NA9Prothrombin 3.4.21.5 0.827
1nt1 T76Prothrombin 3.4.21.5 0.823
2bdy UNBProthrombin 3.4.21.5 0.813
2gde SN3Prothrombin 3.4.21.5 0.813
2zda 32UProthrombin 3.4.21.5 0.806
2zhe 13UProthrombin 3.4.21.5 0.805
3biv 11UProthrombin 3.4.21.5 0.797
3plp BBACationic trypsin 3.4.21.4 0.796
1ypl RA8Prothrombin 3.4.21.5 0.794
2zhw 12UProthrombin 3.4.21.5 0.788
2zgx 29UProthrombin 3.4.21.5 0.787
1lpk CBBCoagulation factor X 3.4.21.6 0.786
1nzq 162Prothrombin 3.4.21.5 0.786
4ayy 9MXProthrombin 3.4.21.5 0.781
1k21 IGNProthrombin 3.4.21.5 0.773
1ta6 177Prothrombin 3.4.21.5 0.772
1ype UIPProthrombin 3.4.21.5 0.765
2cf8 ESHProthrombin 3.4.21.5 0.761
1wqv PSMCoagulation factor VII 3.4.21.21 0.760
1o0d 163Prothrombin 3.4.21.5 0.759
1c4v IH2Prothrombin 3.4.21.5 0.757
2v3o I26Prothrombin 3.4.21.5 0.756
2v3h I25Prothrombin 3.4.21.5 0.753
3qwc 98PProthrombin 3.4.21.5 0.751
3hat GLY_VAL_ARG_RNGProthrombin 3.4.21.5 0.749
4ax9 N5NProthrombin 3.4.21.5 0.748
2zf0 51UProthrombin 3.4.21.5 0.741
3v0x ANHCationic trypsin 3.4.21.4 0.739
1c4u IH1Prothrombin 3.4.21.5 0.735
2zff 53UProthrombin 3.4.21.5 0.731
3dux 64UProthrombin 3.4.21.5 0.731
1wtg 3BPCoagulation factor VII 3.4.21.21 0.730
1ghv 120Prothrombin 3.4.21.5 0.729
5cmx 0G6Prothrombin 3.4.21.5 0.729
1c5n ESIProthrombin 3.4.21.5 0.728
2c4f GILCoagulation factor VII 3.4.21.21 0.724
1ae8 AZLProthrombin 3.4.21.5 0.723
1ypk CCRProthrombin 3.4.21.5 0.722
1ta2 176Prothrombin 3.4.21.5 0.720
2cn0 F25Prothrombin 3.4.21.5 0.718
1vzq SHYProthrombin 3.4.21.5 0.717
1zsk 421Coagulation factor XI 3.4.21.27 0.712
3p17 99PProthrombin 3.4.21.5 0.712
1xm1 GAHProthrombin 3.4.21.5 0.711
2zdv 37UProthrombin 3.4.21.5 0.708
2cf9 348Prothrombin 3.4.21.5 0.706
3qtv 06PProthrombin 3.4.21.5 0.706
1f92 UKPUrokinase-type plasminogen activator 3.4.21.73 0.705
2zc9 22UProthrombin 3.4.21.5 0.703
1wv7 5PICoagulation factor VII 3.4.21.21 0.701
3dhk 23UProthrombin 3.4.21.5 0.701
1mu8 CDBProthrombin 3.4.21.5 0.699
1nm6 L86Prothrombin 3.4.21.5 0.699
1mu6 CDAProthrombin 3.4.21.5 0.697
3biu 10UProthrombin 3.4.21.5 0.697
1ypj UIBProthrombin 3.4.21.5 0.695
3c27 DKKProthrombin 3.4.21.5 0.688
2zfp 19UProthrombin 3.4.21.5 0.687
1vja 7INUrokinase-type plasminogen activator 3.4.21.73 0.686
2r2m I50Prothrombin 3.4.21.5 0.684
2zp0 PI0Coagulation factor VII 3.4.21.21 0.684
3qto 10PProthrombin 3.4.21.5 0.684
1sl3 170Prothrombin 3.4.21.5 0.683
4az2 9MUProthrombin 3.4.21.5 0.683
1ypg UIRProthrombin 3.4.21.5 0.678
1t4u 81AProthrombin 3.4.21.5 0.677
1z71 L17Prothrombin 3.4.21.5 0.676
1lqd CMICoagulation factor X 3.4.21.6 0.674
3eq0 2TSProthrombin 3.4.21.5 0.667
1mue CDDProthrombin 3.4.21.5 0.662
3c1k T15Prothrombin 3.4.21.5 0.661
1uvs I11Prothrombin 3.4.21.5 0.660
2y82 930Coagulation factor X 3.4.21.6 0.658
1kts C24Prothrombin 3.4.21.5 0.655
1ny2 ARG_PRO_PRO_GLYProthrombin 3.4.21.5 0.655
1owi 426Urokinase-type plasminogen activator 3.4.21.73 0.655
4ayv 9MQProthrombin 3.4.21.5 0.653
1sb1 165Prothrombin 3.4.21.5 0.650