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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1k02 FMN NADPH dehydrogenase 1 1.6.99.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 1.263
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.885
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.869
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.866
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.859
4tmc FMNOld yellow enzyme / 0.857
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.856
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.849
4tmb FMNOld yellow enzyme / 0.845
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.844
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.836
1h63 FMNPentaerythritol tetranitrate reductase / 0.835
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.830
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.827
3p62 FMNPentaerythritol tetranitrate reductase / 0.827
4utk FNRXenobiotic reductase / 0.823
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.820
3p74 FMNPentaerythritol tetranitrate reductase / 0.816
3p82 FMNPentaerythritol tetranitrate reductase / 0.814
1h50 FMNPentaerythritol tetranitrate reductase / 0.807
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.807
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.806
3p67 FMNPentaerythritol tetranitrate reductase / 0.804
1vyr FMNPentaerythritol tetranitrate reductase / 0.803
2h8x FMNXenA / 0.803
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.801
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.796
4e2d FMNDehydrogenase / 0.794
1h51 FMNPentaerythritol tetranitrate reductase / 0.790
2abb FMNPentaerythritol tetranitrate reductase / 0.790
3f03 FMNPentaerythritol tetranitrate reductase / 0.789
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.784
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.784
3n19 FNRXenobiotic reductase / 0.783
3atz FMNProstaglandin F2a synthase / 0.782
2zfa FMNLactate oxidase / 0.781
3l67 FMNXenobiotic reductase / 0.780
4e2b FMNDehydrogenase / 0.780
4jic FMNGTN Reductase / 0.778
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.777
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.776
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.776
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.774
2nli FMNLactate oxidase / 0.774
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.774
3p84 FMNPentaerythritol tetranitrate reductase / 0.770
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.768
4uth FMNXenobiotic reductase / 0.767
3l5l FMNXenobiotic reductase / 0.764
3p8i FMNPentaerythritol tetranitrate reductase / 0.764
5cpm FNRNADH:flavin oxidoreductase / 0.764
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.758
4qai FMNNADPH dehydrogenase / 0.752
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.750
4utl FNRXenobiotic reductase / 0.749
4utm FNRXenobiotic reductase / 0.749
1gwj FMNMorphinone reductase / 0.748
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.744
2j6x FMNLactate oxidase / 0.743
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.742
3p8j FMNPentaerythritol tetranitrate reductase / 0.742
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.740
3gka FMNN-ethylmaleimide reductase / 0.740
1z41 FMNNADPH dehydrogenase / 0.735
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.735
2e77 FMNLactate oxidase / 0.723
3n14 FMNXenobiotic reductase / 0.723
3tjl FMNNADPH dehydrogenase / 0.719
1z48 FMNNADPH dehydrogenase / 0.716
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.715
4df2 FMNNADPH dehydrogenase / 0.715
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.715
4rje FNRLactate oxidase / 0.713
4m5p FMNNADPH dehydrogenase / 0.712
4yco FMNtRNA-dihydrouridine(16) synthase / 0.711
3hf3 FMNChromate reductase / 0.706
1vhn FMNtRNA-dihydrouridine synthase / 0.694
3aty FMNProstaglandin F2a synthase / 0.689
2z6i FMN2-nitropropane dioxygenase / 0.688
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.686
5ebu FMNLactate oxidase / 0.682
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 0.678
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.674
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.670
1szg FNSCytochrome b2, mitochondrial 1.1.2.3 0.669
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.661
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.661
2a1t FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.660
2b3d FADModulator of drug activity B / 0.659
4z38 FMNMlnA / 0.659
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.658
1krh FADBenzoate 1,2-dioxygenase electron transfer component 1.18.1.3 0.658
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 0.656
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.655
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.653
4nmc FADBifunctional protein PutA / 0.653
1h66 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.652
1siq FADGlutaryl-CoA dehydrogenase, mitochondrial 1.3.8.6 0.651
3gr8 FMNNADPH dehydrogenase / 0.650