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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1juv NDP Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1juv NDPDihydrofolate reductase 1.5.1.3 1.085
2w3b NDPDihydrofolate reductase 1.5.1.3 0.774
8dfr NDPDihydrofolate reductase 1.5.1.3 0.718
3nxx NDPDihydrofolate reductase 1.5.1.3 0.716
4kl9 NDPDihydrofolate reductase 1.5.1.3 0.713
3kjs NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.710
1dr5 NAPDihydrofolate reductase 1.5.1.3 0.709
3d84 NDPDihydrofolate reductase 1.5.1.3 0.706
3inv NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.680
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.678
3tqa NDPDihydrofolate reductase / 0.671
4xt5 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.667
1drh NAPDihydrofolate reductase 1.5.1.3 0.666
1j3k NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.660
3kjr NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.653
2cig 1DGDihydrofolate reductase 1.5.1.3 0.652
4b7x NAPProbable oxidoreductase / 0.652