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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1jom FFO Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1jom FFODihydrofolate reductase 1.5.1.3 1.048
1dyj DDFDihydrofolate reductase 1.5.1.3 0.908
1jol FFODihydrofolate reductase 1.5.1.3 0.874
4kjj FOLDihydrofolate reductase 1.5.1.3 0.818
4x5f FOLDihydrofolate reductase 1.5.1.3 0.812
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.811
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.795
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.795
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.789
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.788
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.786
1dyi FOLDihydrofolate reductase 1.5.1.3 0.784
4i1n FOLDihydrofolate reductase 1.5.1.3 0.775
5ccc DDFDihydrofolate reductase 1.5.1.3 0.775
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.774
1re7 FOLDihydrofolate reductase 1.5.1.3 0.772
4x5g FOLDihydrofolate reductase 1.5.1.3 0.772
3drc MTXDihydrofolate reductase 1.5.1.3 0.758
1dhj MTXDihydrofolate reductase 1.5.1.3 0.757
3dau MTXDihydrofolate reductase 1.5.1.3 0.755
1df7 MTXDihydrofolate reductase 1.5.1.3 0.754
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.754
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.754
4x5h FOLDihydrofolate reductase 1.5.1.3 0.753
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.752
4fhb FOLDihydrofolate reductase 1.5.1.3 0.750
5hi6 MTXDihydrofolate reductase / 0.749
4p66 MTXDihydrofolate reductase / 0.748
2zza FOLDihydrofolate reductase / 0.747
2drc MTXDihydrofolate reductase 1.5.1.3 0.743
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.742
4dfr MTXDihydrofolate reductase 1.5.1.3 0.742
1hfr MOTDihydrofolate reductase 1.5.1.3 0.740
3tqb FOLDihydrofolate reductase / 0.738
7dfr FOLDihydrofolate reductase 1.5.1.3 0.737
1dra MTXDihydrofolate reductase 1.5.1.3 0.736
3dfr MTXDihydrofolate reductase 1.5.1.3 0.735
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.734
1dhi MTXDihydrofolate reductase 1.5.1.3 0.732
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.732
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.732
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.732
1drb MTXDihydrofolate reductase 1.5.1.3 0.729
4keb FOLDihydrofolate reductase 1.5.1.3 0.728
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.727
4i13 FOLDihydrofolate reductase 1.5.1.3 0.726
1dre MTXDihydrofolate reductase 1.5.1.3 0.723
2qk8 MTXDihydrofolate reductase / 0.722
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.720
3och 2MXDihydrofolate reductase 1.5.1.3 0.720
3ia4 MTXDihydrofolate reductase / 0.718
4m6k FOLDihydrofolate reductase 1.5.1.3 0.717
3eig MTXDihydrofolate reductase 1.5.1.3 0.716
2d0k FOLDihydrofolate reductase 1.5.1.3 0.715
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.715
1u72 MTXDihydrofolate reductase 1.5.1.3 0.713
3ghw GHWDihydrofolate reductase 1.5.1.3 0.711
1e26 GPBDihydrofolate reductase 1.5.1.3 0.710
4qi9 MTXDihydrofolate reductase / 0.710
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.709
3tq9 MTXDihydrofolate reductase / 0.708
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.708
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.702
4p68 MTXDihydrofolate reductase / 0.702
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.699
1hfq MOTDihydrofolate reductase 1.5.1.3 0.699
1dls MTXDihydrofolate reductase 1.5.1.3 0.698
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.696
1ddr MTXDihydrofolate reductase 1.5.1.3 0.691
1u70 MTXDihydrofolate reductase 1.5.1.3 0.687
1drf FOLDihydrofolate reductase 1.5.1.3 0.683
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.680
1dhf FOLDihydrofolate reductase 1.5.1.3 0.679
4kfj FOLDihydrofolate reductase 1.5.1.3 0.678
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.675
1hfp MOTDihydrofolate reductase 1.5.1.3 0.674
4x5i FOLDihydrofolate reductase 1.5.1.3 0.673
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.669
3frd DHFDihydrofolate reductase 1.5.1.3 0.667
4m6l 21VDihydrofolate reductase 1.5.1.3 0.667
2w3m FOLDihydrofolate reductase 1.5.1.3 0.659
2g1m 4HGEgl nine homolog 1 / 0.657
1ao8 MTXDihydrofolate reductase 1.5.1.3 0.656
3dat MTXDihydrofolate reductase / 0.654
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.653
3ghv GHCDihydrofolate reductase 1.5.1.3 0.653
1dds MTXDihydrofolate reductase 1.5.1.3 0.652
4bqs K2QShikimate kinase 2.7.1.71 0.650