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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1j3j CP6 Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1j3j CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.880
3qg2 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.813
2bl9 CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.792
2bla CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.765
2blb CP7Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.759
4ddr MMVDihydrofolate reductase 1.5.1.3 0.725
2blc CP7Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.724
3um5 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.706
3qgt CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.705
3qfx CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.683
1ia1 TQ3Dihydrofolate reductase 1.5.1.3 0.671
1ia2 TQ4Dihydrofolate reductase 1.5.1.3 0.671
4h98 14QUncharacterized protein / 0.664
3qlz QLZUncharacterized protein / 0.663
3eel 53TUncharacterized protein / 0.661
1hfq MOTDihydrofolate reductase 1.5.1.3 0.659
3sa2 7DRDihydrofolate reductase / 0.659
4kne 1CYDihydrofolate reductase 1.5.1.3 0.652
3um8 1CYBifunctional dihydrofolate reductase-thymidylate synthase / 0.651
4h96 14QDihydrofolate reductase 1.5.1.3 0.651
3sqy Q11Dihydrofolate reductase 1.5.1.3 0.650