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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1j1c ADP Glycogen synthase kinase-3 beta 2.7.11.26

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.954
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.840
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.840
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.833
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.829
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.820
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.819
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.810
5ce3 ADPProtein kinase YopO / 0.806
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.802
5dt3 ATPAurora kinase A 2.7.11.1 0.802
4qny ANPMitogen activated protein kinase, putative / 0.801
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.799
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.795
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.793
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.792
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.784
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.784
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.784
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.783
5dos ATPAurora kinase A 2.7.11.1 0.783
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.782
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.780
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.779
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.778
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.778
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.777
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.777
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.776
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.776
5dr2 ATPAurora kinase A 2.7.11.1 0.776
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.773
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.773
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.772
5dn3 ATPAurora kinase A 2.7.11.1 0.772
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.770
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.769
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.769
1cm8 ANPMitogen-activated protein kinase 12 / 0.768
4xlv ACPInsulin receptor 2.7.10.1 0.768
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.763
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.761
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.758
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.757
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.757
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.756
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.756
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.754
2pui ADPMethylthioribose kinase 2.7.1.100 0.750
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.750
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.749
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.749
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.748
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.747
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.747
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.746
4dee ADPAurora kinase A 2.7.11.1 0.745
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.744
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.743
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.743
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.742
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.742
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.741
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.738
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.737
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.736
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.736
4ceg ADPAurora kinase A 2.7.11.1 0.736
1mq4 ADPAurora kinase A 2.7.11.1 0.733
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.733
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.733
5dt4 ATPAurora kinase A 2.7.11.1 0.733
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.731
5drd ATPAurora kinase A 2.7.11.1 0.731
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.730
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.730
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.729
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.729
3c4z ADPRhodopsin kinase / 0.728
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.728
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.727
3qc9 ADPRhodopsin kinase / 0.727
4utd ACPAurora kinase A 2.7.11.1 0.726
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.726
3cly ACPFibroblast growth factor receptor 2 / 0.725
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.724
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.724
1m0w ANPGlutathione synthetase 6.3.2.3 0.723
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.723
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.722
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.722
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.721
3bu5 ATPInsulin receptor 2.7.10.1 0.721
3pff ADPATP-citrate synthase 2.3.3.8 0.721
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.720
2olc ADPMethylthioribose kinase 2.7.1.100 0.720
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.720
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.720
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.719
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.719
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.718
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.717
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.716
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.716
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.715
2pun ACPMethylthioribose kinase 2.7.1.100 0.715
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.715
2pup ADPMethylthioribose kinase 2.7.1.100 0.714
5dnr ATPAurora kinase A 2.7.11.1 0.714
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.712
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.711
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.710
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.710
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.709
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.709
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.708
2wtk ANPSTE20-related kinase adapter protein alpha / 0.707
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.707
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.707
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.705
5eg3 ACPFibroblast growth factor receptor 2 / 0.705
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.704
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.704
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.704
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.702
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.702
4gyi ADPUncharacterized protein / 0.702
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.701
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.701
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.700
2pul ACPMethylthioribose kinase 2.7.1.100 0.700
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.700
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.700
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.699
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.699
2dwb ANPAurora kinase A 2.7.11.1 0.698
3g8d ADPBiotin carboxylase 6.3.4.14 0.697
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.697
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.696
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.696
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
4ysj ADPCalmodulin-like domain protein kinase / 0.696
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.695
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.695
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.694
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.693
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.693
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.692
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.691
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.690
2pml ANPUncharacterized protein / 0.689
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.689
1ol5 ADPAurora kinase A 2.7.11.1 0.688
1u54 ACPActivated CDC42 kinase 1 / 0.688
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.688
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.688
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.688
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.688
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.687
3rv4 ADPBiotin carboxylase 6.3.4.14 0.687
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.686
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.686
2zoq 5IDMitogen-activated protein kinase 3 2.7.11.24 0.686
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.686
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.685
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.684
4ffl ADPUncharacterized protein / 0.684
4o0u ADNAurora kinase A 2.7.11.1 0.684
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.683
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.683
1ol6 ATPAurora kinase A 2.7.11.1 0.682
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.682
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.681
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.681
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.680
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.680
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.680
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.680
1jst ATPCyclin-dependent kinase 2 2.7.11.22 0.679
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.679
2pz5 ACPFibroblast growth factor receptor 2 / 0.678
3q5i ANPProtein kinase, putative / 0.678
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.676
2py3 ACPFibroblast growth factor receptor 2 / 0.676
4o4f ATPKinase / 0.676
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.675
4o0w ADNAurora kinase A 2.7.11.1 0.674
2pyw ADPMethylthioribose kinase 2.7.1.100 0.673
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.673
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.673
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.672
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.672
3nie ANPMitogen-activated protein kinase / 0.672
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.672
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.671
2pwl ACPFibroblast growth factor receptor 2 / 0.671
3tw6 ADPPyruvate carboxylase / 0.671
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.670
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.670
4ffr ATPUncharacterized protein / 0.670
5c1p ADPD-alanine--D-alanine ligase / 0.670
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.669
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.669
4fu0 ADPD-alanine--D-alanine ligase / 0.669
4ork GDPBifunctional AAC/APH 2.3.1 0.668
4q5h ANPProtein kinase OspG 2.7 0.668
3g6w GTPUracil phosphoribosyltransferase 2.4.2.9 0.667
4bn1 ADPAurora kinase A 2.7.11.1 0.666
4dt8 ADNAPH(2'')-Id / 0.666
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.666
5iqa GNPBifunctional AAC/APH 2.3.1 0.665
3t8o ATPRhodopsin kinase / 0.664
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.664
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.663
4n57 ADPAPH(2'')-Id / 0.663
5iqb GNPBifunctional AAC/APH 2.3.1 0.662
1gy3 ATPCyclin-dependent kinase 2 2.7.11.22 0.661
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.661
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.660
2vo0 M03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
3wo1 ADPAlanine--anticapsin ligase / 0.660
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.660
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.659
3g8c ADPBiotin carboxylase 6.3.4.14 0.659
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.659
1fq1 ATPCyclin-dependent kinase 2 2.7.11.22 0.658
1ol7 ADPAurora kinase A 2.7.11.1 0.658
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.658
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.658
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.657
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.657
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.657
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.657
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.656
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.656
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.655
1pxj CK2Cyclin-dependent kinase 2 2.7.11.22 0.654
3ibq ATPPyridoxal kinase / 0.654
1fin ATPCyclin-dependent kinase 2 2.7.11.22 0.653
2j9g ANPBiotin carboxylase 6.3.4.14 0.653
3c50 ADPRhodopsin kinase / 0.653
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.653
4bwa N0BPyrrolysine--tRNA ligase / 0.652
1eq2 ADQADP-L-glycero-D-manno-heptose-6-epimerase / 0.651
2pzp ACPFibroblast growth factor receptor 2 / 0.651
2r7n ADP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase / 0.651
2wqe ADPAurora kinase A 2.7.11.1 0.651
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.651
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.651
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.651
1e1v CMGCyclin-dependent kinase 2 2.7.11.22 0.650
3tdw GDPGentamicin resistance protein / 0.650
5iqi GNPBifunctional AAC/APH 2.3.1 0.650