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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1j0x NAD Glyceraldehyde-3-phosphate dehydrogenase 1.2.1.12

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1j0x NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.930
4o63 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.820
1vsv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.818
1u8f NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.812
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.807
4k9d NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.791
3pym NADGlyceraldehyde-3-phosphate dehydrogenase 3 1.2.1.12 0.780
3cif NADGlyceraldehyde-3-phosphate dehydrogenase / 0.778
1cer NADGlyceraldehyde-3-phosphate dehydrogenase / 0.772
3ids NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.772
1dc6 NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.771
2b4r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.768
1szj NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.766
2vyv NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.762
3v1y NADGlyceraldehyde-3-phosphate dehydrogenase 1, cytosolic 1.2.1.12 0.762
3zcx NADGlyceraldehyde-3-phosphate dehydrogenase / 0.762
4lsm NADGlyceraldehyde-3-phosphate dehydrogenase / 0.758
1ywg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.754
1znq NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.752
1a7k NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.750
2g82 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.744
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.742
1nq5 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.740
1gd1 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.739
4boy NADGlyceraldehyde-3-phosphate dehydrogenase / 0.739
3cmc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.736
4o59 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.735
1hdg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.734
1nqo NADGlyceraldehyde-3-phosphate dehydrogenase / 0.734
1gad NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.732
3cps NADGlyceraldehyde-3-phosphate dehydrogenase / 0.732
1nbo NADGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.724
3hja NADGlyceraldehyde-3-phosphate dehydrogenase / 0.724
4p8r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.724
3doc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.722
3lvf NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.721
4z0h NADGlyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic 1.2.1.12 0.721
1nqa NADGlyceraldehyde-3-phosphate dehydrogenase / 0.719
2d2i NAPGlyceraldehyde-3-phosphate dehydrogenase / 0.716
3l4s NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.715
2ep7 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.713
4dbv NDPGlyceraldehyde-3-phosphate dehydrogenase / 0.713
3dmt NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.707
2vyn NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.705
3adp NAILambda-crystallin 1.1.1.45 0.705
3ksd NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.704
3qv1 NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.703
1npt NADGlyceraldehyde-3-phosphate dehydrogenase / 0.700
2pkr NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.700
1jn0 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.699
3k2b NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.698
3b20 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.694
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.688
3oet NADErythronate-4-phosphate dehydrogenase / 0.688
3e5r NADGlyceraldehyde-3-phosphate dehydrogenase 1, cytosolic 1.2.1.12 0.687
1pjc NADAlanine dehydrogenase / 0.686
3wsw NADL-lactate dehydrogenase / 0.686
1gv0 NADMalate dehydrogenase / 0.685
1rm3 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.685
3ggo NAIPrephenate dehydrogenase / 0.685
4xq9 NADHomospermidine synthase 2.5.1.44 0.683
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.682
1ihx SNDGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.682
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.681
2o4c NADErythronate-4-phosphate dehydrogenase / 0.681
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.681
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.680
3keo NADRedox-sensing transcriptional repressor Rex / 0.679
1uxk NADMalate dehydrogenase / 0.678
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.678
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.677
4j49 NADUncharacterized protein / 0.677
4j4b NAIUncharacterized protein / 0.676
4k28 NADShikimate dehydrogenase family protein / 0.676
1vc2 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.675
2hu2 NADC-terminal binding protein 1 / 0.673
3hdh NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.673
1lso NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.670
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.669
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.669
3jv7 NADSecondary alcohol dehydrogenase / 0.669
4j49 NAIUncharacterized protein / 0.669
4j43 NADUncharacterized protein / 0.668
4plp NADHomospermidine synthase 2.5.1.44 0.668
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.668
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.667
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.667
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.666
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.666
2g5c NADPrephenate dehydrogenase / 0.666
2x0i NAIMalate dehydrogenase / 0.666
4om8 NAD3-hydroxybutyryl-coA dehydrogenase / 0.666
3dbv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.664
3zdf NADGlyceraldehyde-3-phosphate dehydrogenase / 0.664
1uxj NADMalate dehydrogenase / 0.663
1gyp NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.662
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.662
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.662
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.661
2dbz NAPGlyoxylate reductase 1.1.1.26 0.661
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.660
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.660
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.660
1f8f NADBenzyl alcohol dehydrogenase / 0.658
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.658
4c4o NADSADH / 0.658
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.657
1f17 NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.656
2nad NADFormate dehydrogenase / 0.655
3ket NADRedox-sensing transcriptional repressor Rex / 0.655
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.655
3b1j NADGlyceraldehyde-3-phosphate dehydrogenase / 0.654
4gl4 NAIAlcohol dehydrogenase class-3 / 0.654
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.654
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.653
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.650