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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ig1 ANP Death-associated protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 1.018
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.949
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.938
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.905
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.904
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.863
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.858
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.844
4ysj ADPCalmodulin-like domain protein kinase / 0.820
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.817
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.814
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.812
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.812
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.809
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.803
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.799
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.799
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.795
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.793
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.793
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.792
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.792
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.788
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.787
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.787
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.786
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.785
4utd ACPAurora kinase A 2.7.11.1 0.785
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.782
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.781
1mq4 ADPAurora kinase A 2.7.11.1 0.780
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.779
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.777
3c4z ADPRhodopsin kinase / 0.776
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.776
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.772
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.771
5dn3 ATPAurora kinase A 2.7.11.1 0.770
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.769
4dee ADPAurora kinase A 2.7.11.1 0.769
5dt3 ATPAurora kinase A 2.7.11.1 0.767
5dt4 ATPAurora kinase A 2.7.11.1 0.767
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.764
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.764
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.764
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.763
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.762
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.762
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.761
3qc9 ADPRhodopsin kinase / 0.761
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.759
5dos ATPAurora kinase A 2.7.11.1 0.759
5drd ATPAurora kinase A 2.7.11.1 0.759
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.758
4qny ANPMitogen activated protein kinase, putative / 0.758
5dr2 ATPAurora kinase A 2.7.11.1 0.758
3nie ANPMitogen-activated protein kinase / 0.756
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.756
4ceg ADPAurora kinase A 2.7.11.1 0.754
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.754
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.753
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.751
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.749
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.748
2olc ADPMethylthioribose kinase 2.7.1.100 0.747
5ce3 ADPProtein kinase YopO / 0.746
4bn1 ADPAurora kinase A 2.7.11.1 0.745
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.743
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.743
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.742
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.742
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.741
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.740
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.740
3c50 ADPRhodopsin kinase / 0.740
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.740
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.737
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.736
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.735
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.734
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.734
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.733
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.731
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.731
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.730
2dwb ANPAurora kinase A 2.7.11.1 0.729
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.729
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.728
4xlv ACPInsulin receptor 2.7.10.1 0.728
1ol5 ADPAurora kinase A 2.7.11.1 0.727
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.726
3cly ACPFibroblast growth factor receptor 2 / 0.725
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.725
3t8o ATPRhodopsin kinase / 0.725
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.724
1ol6 ATPAurora kinase A 2.7.11.1 0.724
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.724
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.724
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
4o1p ANPRibonuclease L / 0.723
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.721
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.721
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.721
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.721
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.721
5dnr ATPAurora kinase A 2.7.11.1 0.720
2yaa ATPDeath-associated protein kinase 2 / 0.719
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.719
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.718
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.718
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.718
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.717
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.717
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.717
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.717
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.714
2pul ACPMethylthioribose kinase 2.7.1.100 0.714
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.714
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.714
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.713
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.713
3bu5 ATPInsulin receptor 2.7.10.1 0.713
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.713
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.712
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.712
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
2vqd AP2Biotin carboxylase 6.3.4.14 0.711
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
4q5h ANPProtein kinase OspG 2.7 0.711
1u54 ACPActivated CDC42 kinase 1 / 0.710
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.710
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.710
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.710
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.708
3wnz ADPAlanine--anticapsin ligase / 0.706
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.706
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.705
4ork GDPBifunctional AAC/APH 2.3.1 0.705
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.704
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.704
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.703
3q5i ANPProtein kinase, putative / 0.702
2pup ADPMethylthioribose kinase 2.7.1.100 0.701
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.701
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.701
5iqf GDPBifunctional AAC/APH 2.3.1 0.701
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.699
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.698
3c4w ATPRhodopsin kinase / 0.698
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.698
3orm AGSSerine/threonine protein kinase / 0.698
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.698
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.697
2pui ADPMethylthioribose kinase 2.7.1.100 0.696
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.696
2pyw ADPMethylthioribose kinase 2.7.1.100 0.695
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.694
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.694
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.694
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.693
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.693
5iqb GNPBifunctional AAC/APH 2.3.1 0.693
2pun ACPMethylthioribose kinase 2.7.1.100 0.692
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.691
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.691
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.691
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.690
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.689
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.689
1m0w ANPGlutathione synthetase 6.3.2.3 0.688
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.688
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.688
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.687
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.687
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.687
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.686
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.685
3wo0 ADPAlanine--anticapsin ligase / 0.685
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.684
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
3wo1 ADPAlanine--anticapsin ligase / 0.682
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.682
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.681
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.681
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.681
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.680
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.679
3c4x ATPRhodopsin kinase / 0.679
3lmi ATPMyosin heavy chain kinase A 2.7.11.7 0.679
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.679
4zgn ATPCell division cycle protein 123 / 0.678
5byl GCPBifunctional AAC/APH 2.3.1 0.678
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.677
4zs4 ATPMyosin heavy chain kinase A 2.7.11.7 0.677
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.676
4ffl ADPUncharacterized protein / 0.676
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.676
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.674
3r5f ATPD-alanine--D-alanine ligase / 0.673
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.673
4ffm ADPUncharacterized protein / 0.673
4ix5 ANPUncharacterized protein / 0.673
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.672
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.672
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.671
4c3r ACPAurora kinase A 2.7.11.1 0.671
3oro AGSSerine/threonine protein kinase / 0.670
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.670
4o0u ADNAurora kinase A 2.7.11.1 0.670
1ol7 ADPAurora kinase A 2.7.11.1 0.667
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.667
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.667
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.667
3hrc ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.665
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.665
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.664
4gyi ADPUncharacterized protein / 0.664
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.663
5ckw ANPUncharacterized protein / 0.663
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.662
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.662
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.662
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.662
4n57 ADPAPH(2'')-Id / 0.662
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.662
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.661
2wqe ADPAurora kinase A 2.7.11.1 0.661
2zdg ADPD-alanine--D-alanine ligase / 0.661
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.661
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.661
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.660
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.660
4mam A12N5-carboxyaminoimidazole ribonucleotide synthase / 0.660
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.659
1jst ATPCyclin-dependent kinase 2 2.7.11.22 0.658
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.658
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.657
5iqi GNPBifunctional AAC/APH 2.3.1 0.657
1pk8 ATPSynapsin-1 / 0.656
3tdv GDPGentamicin resistance protein / 0.656
3tdw GDPGentamicin resistance protein / 0.656
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.655
2fsn ADPArchaeal actin homolog / 0.655
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.655
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.654
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.654
5iqh GNPBifunctional AAC/APH 2.3.1 0.654
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.653
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.653
5iqa GNPBifunctional AAC/APH 2.3.1 0.653
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.652
2ydo ADNAdenosine receptor A2a / 0.652
4ffr ATPUncharacterized protein / 0.652
5l6w AGSLIM domain kinase 1 2.7.11.1 0.652
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.651
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.650
2biy ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.650