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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1iah ADP Transient receptor potential cation channel subfamily M member 7 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1iah ADPTransient receptor potential cation channel subfamily M member 7 2.7.11.1 1.001
4zme ADNMyosin heavy chain kinase A 2.7.11.7 0.752
3lla ACPMyosin heavy chain kinase A 2.7.11.7 0.743
4ffm ADPUncharacterized protein / 0.741
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.737
3pdt ADPMyosin heavy chain kinase A 2.7.11.7 0.729
3eps ATPIsocitrate dehydrogenase kinase/phosphatase / 0.720
4ffr ATPUncharacterized protein / 0.719
2r7n ADP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase / 0.718
3tw6 ADPPyruvate carboxylase / 0.718
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.716
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.715
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.707
1px2 ATPSynapsin-1 / 0.705
4mv3 ACPBiotin carboxylase 6.3.4.14 0.705
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.704
4fu0 ADPD-alanine--D-alanine ligase / 0.704
4ffl ADPUncharacterized protein / 0.702
4zs4 ATPMyosin heavy chain kinase A 2.7.11.7 0.701
5e9e ANPMyosin heavy chain kinase A 2.7.11.7 0.699
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.698
4mv8 ACPBiotin carboxylase 6.3.4.14 0.698
1ia9 ANPTransient receptor potential cation channel subfamily M member 7 2.7.11.1 0.697
3r5f ATPD-alanine--D-alanine ligase / 0.697
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.695
3wo0 ADPAlanine--anticapsin ligase / 0.695
4mam A12N5-carboxyaminoimidazole ribonucleotide synthase / 0.692
4o4i ACPTubulin tyrosine ligase / 0.691
2r86 ATP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase / 0.690
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.690
2zdg ADPD-alanine--D-alanine ligase / 0.687
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.680
2j9g ADPBiotin carboxylase 6.3.4.14 0.680
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.673
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.671
2p0a ANPSynapsin-3 / 0.667
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.662
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.660
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.660
1mqb ANPEphrin type-A receptor 2 2.7.10.1 0.659
3wnz ADPAlanine--anticapsin ligase / 0.657
2w5a ADPSerine/threonine-protein kinase Nek2 2.7.11.1 0.656
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
1v3s ATPSignaling protein / 0.654
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.653
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.653
5cu6 ATPCasein kinase II subunit alpha 2.7.11.1 0.653
2qmm SAMtRNA (pseudouridine(54)-N(1))-methyltransferase / 0.651