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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1hv5 RXP Stromelysin-3 3.4.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1hv5 RXPStromelysin-3 3.4.24 1.195
4gr8 R4CMacrophage metalloelastase 3.4.24.65 0.783
4gr3 R45Macrophage metalloelastase 3.4.24.65 0.769
2ovz 5MRMatrix metalloproteinase-9 3.4.24.35 0.722
4gr0 R4BMacrophage metalloelastase 3.4.24.65 0.722
1jk3 BATMacrophage metalloelastase 3.4.24.65 0.708
1zvx FINNeutrophil collagenase 3.4.24.34 0.705
2woa 576Macrophage metalloelastase 3.4.24.65 0.702
4gql R47Macrophage metalloelastase 3.4.24.65 0.702
1bzs BSINeutrophil collagenase 3.4.24.34 0.694
1mnc PLHNeutrophil collagenase 3.4.24.34 0.687
2oy2 ILE_ALA_GLYNeutrophil collagenase 3.4.24.34 0.687
2wo9 068Macrophage metalloelastase 3.4.24.65 0.684
1gkc NFHMatrix metalloproteinase-9 3.4.24.35 0.672
3tsk QEGMacrophage metalloelastase 3.4.24.65 0.672
3lil EEAMacrophage metalloelastase 3.4.24.65 0.669
2i47 INNDisintegrin and metalloproteinase domain-containing protein 17 3.4.24.86 0.668
1sln INHStromelysin-1 3.4.24.17 0.665
4dd8 BATDisintegrin and metalloproteinase domain-containing protein 8 3.4.24 0.661
4h76 10BMacrophage metalloelastase 3.4.24.65 0.660
2w14 WR2Snake venom metalloproteinase BaP1 3.4.24 0.658
2dw0 GM6Zinc metalloproteinase-disintegrin-like VAP2B 3.4.24 0.655
2woa 023Macrophage metalloelastase 3.4.24.65 0.653
3hy7 097A disintegrin and metalloproteinase with thrombospondin motifs 5 3.4.24 0.652
3ljg EEFMacrophage metalloelastase 3.4.24.65 0.651