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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1hld NAD Alcohol dehydrogenase E chain 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 1.360
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 1.278
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 1.277
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 1.277
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 1.275
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 1.267
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 1.260
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.259
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.256
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.246
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 1.246
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 1.242
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 1.241
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.231
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.229
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 1.228
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 1.224
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 1.209
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 1.206
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 1.194
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 1.191
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 1.186
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 1.168
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 1.163
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 1.156
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 1.152
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.129
1het NADAlcohol dehydrogenase E chain 1.1.1.1 1.119
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 1.080
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 1.019
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 1.018
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 1.003
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.995
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.962
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.960
1yqd NAPSinapyl alcohol dehydrogenase / 0.935
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.932
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.926
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.913
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.902
3jv7 NADSecondary alcohol dehydrogenase / 0.895
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.888
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.876
3two NDPMannitol dehydrogenase / 0.861
1yqx NAPSinapyl alcohol dehydrogenase / 0.856
3wle NAD(R)-specific carbonyl reductase / 0.838
4c4o NADSADH / 0.826
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.821
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.818
4rqu NADAlcohol dehydrogenase class-P / 0.814
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.811
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.806
1uxj NADMalate dehydrogenase / 0.803
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.801
4oaq NDPR-specific carbonyl reductase / 0.797
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.795
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.795
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.794
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.789
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.788
1u7h NADPutative ornithine cyclodeaminase / 0.783
1x7d NADPutative ornithine cyclodeaminase / 0.780
1gv0 NADMalate dehydrogenase / 0.770
4cpd NADAlcohol dehydrogenase / 0.766
3uko NADAlcohol dehydrogenase class-3 / 0.763
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.757
1pzh NADLactate dehydrogenase / 0.757
1llu NADAlcohol dehydrogenase / 0.756
2dph NADFormaldehyde dismutase / 0.752
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.747
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.746
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.745
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.740
2o4c NADErythronate-4-phosphate dehydrogenase / 0.739
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.739
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.738
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.736
4l0q NADAlcohol dehydrogenase class-3 / 0.731
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.731
5a1t NAIL-lactate dehydrogenase / 0.731
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.730
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.730
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.728
4k28 NADShikimate dehydrogenase family protein / 0.724
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.721
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.720
4xq9 NADHomospermidine synthase 2.5.1.44 0.719
2voj NADAlanine dehydrogenase 1.4.1.1 0.718
1ur5 NADMalate dehydrogenase / 0.717
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.716
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.715
2vhx NADAlanine dehydrogenase 1.4.1.1 0.714
1uxk NADMalate dehydrogenase / 0.713
4jji NADAlcohol dehydrogenase class-3 / 0.713
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.712
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.712
1c1d NAIPhenylalanine dehydrogenase / 0.711
1pj3 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.710
1guy NADMalate dehydrogenase / 0.707
2x0i NAIMalate dehydrogenase / 0.707
1sow NADL-lactate dehydrogenase 1.1.1.27 0.706
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.705
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.704
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.700
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.698
4xqc NADHomospermidine synthase 2.5.1.44 0.697
1b3r NADAdenosylhomocysteinase 3.3.1.1 0.696
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.695
4ejm NAPPutative zinc-binding dehydrogenase / 0.695
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.695
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.693
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.693
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.692
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.692
4b7x NAPProbable oxidoreductase / 0.692
4gl4 NAIAlcohol dehydrogenase class-3 / 0.689
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.686
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.685
4xrg NADHomospermidine synthase 2.5.1.44 0.685
3x2f NAIAdenosylhomocysteinase / 0.684
4tvb NADHomospermidine synthase 2.5.1.44 0.684
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.682
2xaa NADSecondary alcohol dehydrogenase / 0.682
3ggp NADPrephenate dehydrogenase / 0.682
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.680
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.679
3f3s NADLambda-crystallin homolog / 0.679
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.677
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.676
2gsd NADFormate dehydrogenase / 0.676
4plp NADHomospermidine synthase 2.5.1.44 0.676
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.675
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.675
1obb NADAlpha-glucosidase 3.2.1.20 0.674
2x0r NADMalate dehydrogenase / 0.674
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.672
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.671
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.670
4ros APRMalate dehydrogenase / 0.670
1pzf A3DLactate dehydrogenase / 0.669
1o6z NADMalate dehydrogenase / 0.668
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.667
1xcb NADRedox-sensing transcriptional repressor Rex / 0.666
2cda NAPGlucose 1-dehydrogenase / 0.664
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.663
2yvg NADFerredoxin reductase / 0.663
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.663
5ijz NAPNADP-specific glutamate dehydrogenase 1.4.1.4 0.663
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.662
2vwh NAPGlucose 1-dehydrogenase / 0.662
3keo NADRedox-sensing transcriptional repressor Rex / 0.662
1b8u NADMalate dehydrogenase / 0.661
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.661
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.661
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.660
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.660
2g5c NADPrephenate dehydrogenase / 0.659
1gq2 NAPNADP-dependent malic enzyme 1.1.1.40 0.658
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.658
4hb9 FADUncharacterized protein / 0.658
4jbi NDPAlcohol dehydrogenase (Zinc) / 0.658
3w6u NAP6-phosphogluconate dehydrogenase, NAD-binding protein / 0.657
2ome NADC-terminal-binding protein 2 / 0.656
3bts NADGalactose/lactose metabolism regulatory protein GAL80 / 0.656
2x86 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.655
4i1i NADMalate dehydrogenase / 0.655
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 0.654
3kb6 NADD-lactate dehydrogenase / 0.654
1lso NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.653
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.653
2vwq NAPGlucose 1-dehydrogenase / 0.653
4j49 NADUncharacterized protein / 0.653
1ie3 NADMalate dehydrogenase / 0.652
5a02 NAPGlucose-fructose oxidoreductase / 0.652
1ryd NDPGlucose--fructose oxidoreductase 1.1.99.28 0.651
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.651
4jk3 NADUncharacterized protein / 0.651
4z0p NDPNAD-dependent dehydrogenase / 0.651
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.650
4pxz CLRP2Y purinoceptor 12 / 0.650
5a04 NDPGlucose-fructose oxidoreductase / 0.650