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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1hfr MOT Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1hfr MOTDihydrofolate reductase 1.5.1.3 1.076
1hfq MOTDihydrofolate reductase 1.5.1.3 0.988
1hfp MOTDihydrofolate reductase 1.5.1.3 0.958
1dls MTXDihydrofolate reductase 1.5.1.3 0.871
4m6k FOLDihydrofolate reductase 1.5.1.3 0.863
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.827
1dyh DZFDihydrofolate reductase 1.5.1.3 0.823
4x5f FOLDihydrofolate reductase 1.5.1.3 0.810
4x5g FOLDihydrofolate reductase 1.5.1.3 0.805
3eig MTXDihydrofolate reductase 1.5.1.3 0.804
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.803
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.803
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.797
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.796
1dyi FOLDihydrofolate reductase 1.5.1.3 0.788
4i13 FOLDihydrofolate reductase 1.5.1.3 0.787
1e26 GPBDihydrofolate reductase 1.5.1.3 0.785
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.784
1u70 MTXDihydrofolate reductase 1.5.1.3 0.783
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.782
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.780
1dra MTXDihydrofolate reductase 1.5.1.3 0.779
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.779
4dfr MTXDihydrofolate reductase 1.5.1.3 0.779
4kfj FOLDihydrofolate reductase 1.5.1.3 0.779
2zza FOLDihydrofolate reductase / 0.776
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.774
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.773
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.771
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.771
4keb FOLDihydrofolate reductase 1.5.1.3 0.771
2drc MTXDihydrofolate reductase 1.5.1.3 0.769
3och 2MXDihydrofolate reductase 1.5.1.3 0.768
1u72 MTXDihydrofolate reductase 1.5.1.3 0.767
3ia4 MTXDihydrofolate reductase / 0.766
1dyj DDFDihydrofolate reductase 1.5.1.3 0.765
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.765
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.764
3drc MTXDihydrofolate reductase 1.5.1.3 0.764
2qk8 MTXDihydrofolate reductase / 0.761
4x5i FOLDihydrofolate reductase 1.5.1.3 0.761
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.760
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.759
7dfr FOLDihydrofolate reductase 1.5.1.3 0.757
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.755
3dau MTXDihydrofolate reductase 1.5.1.3 0.754
1df7 MTXDihydrofolate reductase 1.5.1.3 0.751
2d0k FOLDihydrofolate reductase 1.5.1.3 0.751
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.747
3ghw GHWDihydrofolate reductase 1.5.1.3 0.747
4kjj FOLDihydrofolate reductase 1.5.1.3 0.747
5ccc DDFDihydrofolate reductase 1.5.1.3 0.747
3td8 D2RDihydrofolate reductase 1.5.1.3 0.746
5hi6 MTXDihydrofolate reductase / 0.745
1drf FOLDihydrofolate reductase 1.5.1.3 0.743
4p66 MTXDihydrofolate reductase / 0.741
1jom FFODihydrofolate reductase 1.5.1.3 0.740
3dfr MTXDihydrofolate reductase 1.5.1.3 0.740
2w3m FOLDihydrofolate reductase 1.5.1.3 0.739
1dhi MTXDihydrofolate reductase 1.5.1.3 0.737
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.733
4x5h FOLDihydrofolate reductase 1.5.1.3 0.733
1dds MTXDihydrofolate reductase 1.5.1.3 0.732
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.732
4qi9 MTXDihydrofolate reductase / 0.730
3tq9 MTXDihydrofolate reductase / 0.723
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.722
4m6l 21VDihydrofolate reductase 1.5.1.3 0.719
1dhj MTXDihydrofolate reductase 1.5.1.3 0.718
1dhf FOLDihydrofolate reductase 1.5.1.3 0.717
4i1n FOLDihydrofolate reductase 1.5.1.3 0.717
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.716
2dhf DZFDihydrofolate reductase 1.5.1.3 0.714
3ghv GHCDihydrofolate reductase 1.5.1.3 0.714
4fhb FOLDihydrofolate reductase 1.5.1.3 0.714
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.711
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.711
1jol FFODihydrofolate reductase 1.5.1.3 0.710
1re7 FOLDihydrofolate reductase 1.5.1.3 0.710
4p68 MTXDihydrofolate reductase / 0.710
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.710
3tqb FOLDihydrofolate reductase / 0.707
1drb MTXDihydrofolate reductase 1.5.1.3 0.706
3gyf 51PDihydrofolate reductase 1.5.1.3 0.702
1tdr MTXDihydrofolate reductase 1.5.1.3 0.698
1ddr MTXDihydrofolate reductase 1.5.1.3 0.697
1ohk COPDihydrofolate reductase 1.5.1.3 0.696
1ly3 COGDihydrofolate reductase 1.5.1.3 0.691
1ohj COPDihydrofolate reductase 1.5.1.3 0.691
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.690
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.686
3frd DHFDihydrofolate reductase 1.5.1.3 0.686
1pd8 CO4Dihydrofolate reductase 1.5.1.3 0.683
3i8a N22Dihydrofolate reductase 1.5.1.3 0.681
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.678
1s3v TQDDihydrofolate reductase 1.5.1.3 0.678
3l3r OAGDihydrofolate reductase 1.5.1.3 0.677
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.674
4ixg IXGDihydrofolate reductase 1.5.1.3 0.673
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.668
3sgy 06WDihydrofolate reductase 1.5.1.3 0.663
1j3k WRABifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.662
1mvs DTMDihydrofolate reductase 1.5.1.3 0.660
3sa2 7DRDihydrofolate reductase / 0.660
4ddr MMVDihydrofolate reductase 1.5.1.3 0.658
4ixf IXFDihydrofolate reductase 1.5.1.3 0.658
4bb3 KKAIsopenicillin N synthase 1.21.3.1 0.657
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.655
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.654
1dre MTXDihydrofolate reductase 1.5.1.3 0.653
4ij1 17CAnthranilate phosphoribosyltransferase / 0.653
1qjf ACSIsopenicillin N synthase 1.21.3.1 0.652
4dph P65Bifunctional dihydrofolate reductase-thymidylate synthase / 0.652
1dyr TOPDihydrofolate reductase 1.5.1.3 0.651
4dp3 MMVBifunctional dihydrofolate reductase-thymidylate synthase / 0.650