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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1heu NAD Alcohol dehydrogenase E chain 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 1.261
1het NADAlcohol dehydrogenase E chain 1.1.1.1 1.254
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 1.239
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.202
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 1.193
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 1.187
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.186
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 1.184
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.171
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 1.171
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 1.171
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 1.170
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 1.170
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 1.167
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 1.154
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 1.150
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.150
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 1.149
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 1.137
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 1.136
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 1.125
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 1.118
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 1.113
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 1.112
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.108
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.102
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 1.099
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 1.094
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 1.084
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 1.070
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 1.003
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.942
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.924
3jv7 NADSecondary alcohol dehydrogenase / 0.895
3wle NAD(R)-specific carbonyl reductase / 0.883
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.880
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.867
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.863
3two NDPMannitol dehydrogenase / 0.860
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.852
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.852
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.848
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.841
1yqd NAPSinapyl alcohol dehydrogenase / 0.815
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.806
4c4o NADSADH / 0.804
1uxj NADMalate dehydrogenase / 0.799
4cpd NADAlcohol dehydrogenase / 0.795
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.794
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.793
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.791
4l0q NADAlcohol dehydrogenase class-3 / 0.783
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.780
4rqu NADAlcohol dehydrogenase class-P / 0.776
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.775
1u7h NADPutative ornithine cyclodeaminase / 0.774
1uxk NADMalate dehydrogenase / 0.773
1x7d NADPutative ornithine cyclodeaminase / 0.772
4jji NADAlcohol dehydrogenase class-3 / 0.767
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.766
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.754
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.754
4oaq NDPR-specific carbonyl reductase / 0.753
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.742
1yqx NAPSinapyl alcohol dehydrogenase / 0.739
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.738
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.726
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.725
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.722
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.720
2x0i NAIMalate dehydrogenase / 0.720
4gl4 NAIAlcohol dehydrogenase class-3 / 0.718
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.717
1f8f NADBenzyl alcohol dehydrogenase / 0.716
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.716
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.713
4j43 NADUncharacterized protein / 0.713
1gv0 NADMalate dehydrogenase / 0.711
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.710
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.708
1o6z NADMalate dehydrogenase / 0.708
2dph NADFormaldehyde dismutase / 0.707
2xaa NADSecondary alcohol dehydrogenase / 0.707
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.706
1pzh NADLactate dehydrogenase / 0.703
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.703
3uko NADAlcohol dehydrogenase class-3 / 0.701
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.697
1up7 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.694
3wsw NADL-lactate dehydrogenase / 0.692
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.690
2vwh NAPGlucose 1-dehydrogenase / 0.688
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.688
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.687
4uun NAIL-lactate dehydrogenase / 0.687
5a1t NAIL-lactate dehydrogenase / 0.686
2cda NAPGlucose 1-dehydrogenase / 0.683
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.683
2cdc NAPGlucose 1-dehydrogenase / 0.682
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.681
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.681
1sow NADL-lactate dehydrogenase 1.1.1.27 0.678
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.676
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.675
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.673
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.673
1pzg A3DLactate dehydrogenase / 0.673
2vhx NADAlanine dehydrogenase 1.4.1.1 0.670
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.670
2voj NADAlanine dehydrogenase 1.4.1.1 0.670
1e3e NAIAlcohol dehydrogenase 4 1.1.1.1 0.669
4i1i NADMalate dehydrogenase / 0.669
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.669
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.667
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.667
1guy NADMalate dehydrogenase / 0.665
2a92 NAIL-lactate dehydrogenase / 0.665
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.665
3x2f NAIAdenosylhomocysteinase / 0.665
4j4b NAIUncharacterized protein / 0.665
3wfj NAD2-dehydropantoate 2-reductase / 0.663
1ib6 NADMalate dehydrogenase / 0.661
2o4c NADErythronate-4-phosphate dehydrogenase / 0.661
1b8v NADMalate dehydrogenase / 0.658
5a02 NAPGlucose-fructose oxidoreductase / 0.658
1wze NADMalate dehydrogenase / 0.657
2yvg NADFerredoxin reductase / 0.657
2p9c NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.656
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.656
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.656
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 0.654
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.653