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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1hck ATP Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1hck ATPCyclin-dependent kinase 2 2.7.11.22 1.085
1b38 ATPCyclin-dependent kinase 2 2.7.11.22 0.949
1b39 ATPCyclin-dependent kinase 2 2.7.11.22 0.804
4m69 ANPReceptor-interacting serine/threonine-protein kinase 3 2.7.11.1 0.756
4zse ANPEpidermal growth factor receptor 2.7.10.1 0.728
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.720
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.711
3rep ATPIntegrin-linked protein kinase 2.7.11.1 0.698
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.693
3lmg ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.686
3kmw ATPIntegrin-linked protein kinase 2.7.11.1 0.677
3ort AGSSerine/threonine protein kinase / 0.676
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.672
1n2g APCPantothenate synthetase 6.3.2.1 0.670
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.669
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.668
1w1w AGSStructural maintenance of chromosomes protein 1 / 0.664
4qml ANPSerine/threonine-protein kinase 24 2.7.11.1 0.659
2rgx AP5Adenylate kinase / 0.657
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.657
4fvr ATPTyrosine-protein kinase JAK2 / 0.657
3myk ANPMyosin-2 heavy chain / 0.652
1bmf ADPATP synthase subunit alpha, mitochondrial / 0.651
1bmf ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.651
3zfd ANPChromosome-associated kinesin KIF4 / 0.651
1h8h ADPATP synthase subunit alpha, mitochondrial / 0.650
1h8h ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.650