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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1hbn TP7 Methyl-coenzyme M reductase I subunit alpha 2.8.4.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1hbn TP7Methyl-coenzyme M reductase I subunit alpha 2.8.4.1 1.290
1hbn TP7Methyl-coenzyme M reductase I subunit beta 2.8.4.1 1.290
1hbm SHTMethyl-coenzyme M reductase I subunit alpha 2.8.4.1 1.220
1hbm SHTMethyl-coenzyme M reductase I subunit beta 2.8.4.1 1.220
4dfr MTXDihydrofolate reductase 1.5.1.3 0.696
1hfq MOTDihydrofolate reductase 1.5.1.3 0.684
3dau MTXDihydrofolate reductase 1.5.1.3 0.677
1df7 MTXDihydrofolate reductase 1.5.1.3 0.672
3och 2MXDihydrofolate reductase 1.5.1.3 0.671
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.669
4i13 FOLDihydrofolate reductase 1.5.1.3 0.668
7dfr FOLDihydrofolate reductase 1.5.1.3 0.659
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.655
1toj HCIAspartate aminotransferase 2.6.1.1 0.653
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.650