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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1gwj FMN Morphinone reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1gwj FMNMorphinone reductase / 1.248
1h63 FMNPentaerythritol tetranitrate reductase / 1.146
3p8i FMNPentaerythritol tetranitrate reductase / 1.123
4tmc FMNOld yellow enzyme / 1.121
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 1.104
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 1.104
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 1.103
4jic FMNGTN Reductase / 1.084
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 1.082
3tjl FMNNADPH dehydrogenase / 1.068
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 1.056
4aws FMNNADH:flavin oxidoreductase Sye1 / 1.045
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 1.036
4df2 FMNNADPH dehydrogenase / 1.017
3atz FMNProstaglandin F2a synthase / 1.016
1oya FMNNADPH dehydrogenase 1 1.6.99.1 1.013
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 1.013
4e2d FMNDehydrogenase / 1.012
3aty FMNProstaglandin F2a synthase / 1.008
4tmb FMNOld yellow enzyme / 1.005
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.997
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.992
4qai FMNNADPH dehydrogenase / 0.991
4e2b FMNDehydrogenase / 0.981
3gka FMNN-ethylmaleimide reductase / 0.970
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.950
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.948
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.945
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.942
1z44 FMNNADPH dehydrogenase / 0.940
3p8j FMNPentaerythritol tetranitrate reductase / 0.933
2abb FMNPentaerythritol tetranitrate reductase / 0.930
3p84 FMNPentaerythritol tetranitrate reductase / 0.929
1z48 FMNNADPH dehydrogenase / 0.922
3n14 FMNXenobiotic reductase / 0.920
3p67 FMNPentaerythritol tetranitrate reductase / 0.919
2h8x FMNXenA / 0.917
1z41 FMNNADPH dehydrogenase / 0.915
3f03 FMNPentaerythritol tetranitrate reductase / 0.914
3p74 FMNPentaerythritol tetranitrate reductase / 0.913
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.911
3l67 FMNXenobiotic reductase / 0.907
3p62 FMNPentaerythritol tetranitrate reductase / 0.903
4m5p FMNNADPH dehydrogenase / 0.896
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.896
1h51 FMNPentaerythritol tetranitrate reductase / 0.893
4uth FMNXenobiotic reductase / 0.881
1h50 FMNPentaerythritol tetranitrate reductase / 0.874
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.873
3l5l FMNXenobiotic reductase / 0.869
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.863
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.857
4utk FNRXenobiotic reductase / 0.855
1vyr FMNPentaerythritol tetranitrate reductase / 0.854
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.849
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.848
3hf3 FMNChromate reductase / 0.846
4utm FNRXenobiotic reductase / 0.843
4utl FNRXenobiotic reductase / 0.842
3p82 FMNPentaerythritol tetranitrate reductase / 0.835
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.831
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.831
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.828
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.827
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 0.827
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.824
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.823
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.820
4yco FMNtRNA-dihydrouridine(16) synthase / 0.819
3n19 FNRXenobiotic reductase / 0.818
5cpm FNRNADH:flavin oxidoreductase / 0.816
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.814
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.810
3gr8 FMNNADPH dehydrogenase / 0.810
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.802
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.801
1vhn FMNtRNA-dihydrouridine synthase / 0.796
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.787
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.785
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.773
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.772
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.769
2j6x FMNLactate oxidase / 0.763
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.754
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.750
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.748
4yl2 FMNLactate oxidase / 0.746
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.745
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.740
5ebu FMNLactate oxidase / 0.736
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.733
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.732
2nli FMNLactate oxidase / 0.732
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.729
2zfa FMNLactate oxidase / 0.725
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.720
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.716
3oix FMNDihydroorotate dehydrogenase / 0.711
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.709
1h66 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.708
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.707
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.706
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.705
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 0.701
4cw5 FMNDfnA / 0.701
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.700
2e77 FMNLactate oxidase / 0.699
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 0.694
1siq FADGlutaryl-CoA dehydrogenase, mitochondrial 1.3.8.6 0.689
3klb FMNUncharacterized protein / 0.688
2gjl FMNNitronate monooxygenase 1.13.12.16 0.687
4zoh FADPutative oxidoreductase FAD-binding subunit / 0.686
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.685
5a4k FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.685
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.684
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.684
5a8a FMNRiboflavin biosynthesis protein RibF 2.7.1.26 0.682
2vyx FMNDodecin / 0.680
3eo8 FMNPutative nitroreductase / 0.680
4ttc FMNIodotyrosine deiodinase 1 / 0.677
4yx6 FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.677
2q9u FMNA-type flavoprotein / 0.674
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.672
4zvn FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.672
3g5m FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.668
3w77 FMNFMN-dependent NADH-azoreductase / 0.667
1nb9 RBFRiboflavin kinase 2.7.1.26 0.666
1dxo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.665
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.658
3bw3 FMNPutative 2-nitropropane dioxygenase / 0.657
2a1t FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.656
2z9d FMNFMN-dependent NADH-azoreductase / 0.656
4bca FADAlkyldihydroxyacetonephosphate synthase, peroxisomal 2.5.1.26 0.656
2qw8 NAPEugenol synthase 1 1.1.1.318 0.655
1udy FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.654
3sf6 FDAGlutaryl-CoA dehydrogenase / 0.654
1jqi FADShort-chain specific acyl-CoA dehydrogenase, mitochondrial / 0.652
2eba FADPutative glutaryl-CoA dehydrogenase / 0.652
5jsc FADPutative acyl-CoA dehydrogenase / 0.652
3gg0 FMNUncharacterized protein / 0.651
1wsb FMNFlavodoxin / 0.650
3qe2 FMNNADPH--cytochrome P450 reductase / 0.650
4r38 RBFBlue-light-activated histidine kinase 2 2.7.13.3 0.650
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.650