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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1g50 EST Estrogen receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1g50 ESTEstrogen receptor / 1.116
3uud ESTEstrogen receptor / 0.910
2yja ESTEstrogen receptor / 0.902
5dxg ESTEstrogen receptor / 0.891
5hyr ESTEstrogen receptor / 0.883
4pxm ESTEstrogen receptor / 0.873
2g5o DRQEstrogen receptor / 0.871
3oll ESTEstrogen receptor beta / 0.868
2qgt EEDEstrogen receptor / 0.867
2j7x ESTEstrogen receptor beta / 0.864
3q95 ESLEstrogen receptor / 0.856
1gwr ESTEstrogen receptor / 0.839
2yat EEUEstrogen receptor / 0.812
2b1z 17MEstrogen receptor / 0.800
5dx3 ESTEstrogen receptor / 0.795
2ocf ESTEstrogen receptor / 0.792
2p15 EZTEstrogen receptor / 0.715
4ofr DHTAndrogen receptor / 0.710
2piw DHTAndrogen receptor / 0.707
1xj7 DHTAndrogen receptor / 0.702
4j6b PLOCytochrome P450 monooxygenase / 0.698
1lhw ESMSex hormone-binding globulin / 0.696
2pkl DHTAndrogen receptor / 0.696
2pio DHTAndrogen receptor / 0.695
2ama DHTAndrogen receptor / 0.689
3w5p 4OAVitamin D3 receptor / 0.689
2pnu ENMAndrogen receptor / 0.688
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.687
3w5q 3KLVitamin D3 receptor / 0.682
1t5z DHTAndrogen receptor / 0.680
1t73 DHTAndrogen receptor / 0.679
1t74 DHTAndrogen receptor / 0.679
3uzx AOM3-oxo-5-beta-steroid 4-dehydrogenase / 0.678
4q0a 4OAVitamin D3 receptor A / 0.675
3uzx AOX3-oxo-5-beta-steroid 4-dehydrogenase / 0.674
3i68 J4ZDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.671
1lri CLRBeta-elicitin cryptogein / 0.668
3gki CLRNiemann-Pick C1 protein / 0.664
2rlc CHDCholoylglycine hydrolase 3.5.1.24 0.663
1p8d CO1Oxysterols receptor LXR-beta / 0.662
3g1r FIT3-oxo-5-beta-steroid 4-dehydrogenase / 0.661
1t65 DHTAndrogen receptor / 0.654
1xf0 ASDAldo-keto reductase family 1 member C3 / 0.653