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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ffi 2NC Gag-Pol polyprotein 3.4.23.16

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
1ffi 2NCGag-Pol polyprotein 3.4.23.16 1.509
1fg6 2NCGag-Pol polyprotein 3.4.23.16 1.466
1fgc 2NCGag-Pol polyprotein 3.4.23.16 1.321
3nwq 2NCGag-Pol polyprotein 3.4.23.16 1.301
3dcr KVSProtease / 1.299
3nxe 2NCProtease / 1.279
2avm 2NCGag-Pol polyprotein 3.4.23.16 1.264
3hzc 2NCProtease / 1.258
3nyg 2NCGag-Pol polyprotein 3.4.23.16 1.225
1ff0 2NCGag-Pol polyprotein 3.4.23.16 1.219
1fej 2NCGag-Pol polyprotein 3.4.23.16 1.207
3dck KVIProtease / 1.203
3bva 2NCGag-Pol polyprotein 3.4.23.16 1.181
3nwx KVSGag-Pol polyprotein 3.4.23.16 1.106
3i2l 2NCProtease / 1.065
2aoe 0Q4Gag-Pol polyprotein 3.4.23.16 0.986
1izh Q50Protease / 0.974
1k2b 0Q4Gag-Pol polyprotein 3.4.23.16 0.968
1a94 0Q4Gag-Pol polyprotein 3.4.23.16 0.946
1fff 0Q4Gag-Pol polyprotein 3.4.23.16 0.934
1dw6 0Q4Gag-Pol polyprotein 3.4.23.16 0.911
1izi Q50Gag-Pol polyprotein 3.4.23.16 0.896
2a1e IPFGag-Pol polyprotein 3.4.23.16 0.887
1k2c 0Q4Gag-Pol polyprotein 3.4.23.16 0.884
1fg8 0Q4Gag-Pol polyprotein 3.4.23.16 0.876
1iiq 0ZRGag-Pol polyprotein 3.4.23.16 0.875
1k1u 0Q4Gag-Pol polyprotein 3.4.23.16 0.856
1daz 0Q4Gag-Pol polyprotein 3.4.23.16 0.855
3kf0 3TLGag-Pol polyprotein / 0.850
3bxr DRRGag-Pol polyprotein 3.4.23.16 0.843
3gga GGWGag-Pol polyprotein / 0.841
1ec1 BEEGag-Pol polyprotein 3.4.23.16 0.839
2cem 2AHPol protein / 0.837
3kfn 3TLGag-Pol polyprotein / 0.831
3oxx DR7Gag-Pol polyprotein 3.4.23.16 0.829
3em4 DR7Gag-Pol polyprotein 3.4.23.16 0.824
2pk5 075Protease / 0.819
3kfr 3TLGag-Pol polyprotein / 0.817
1b6k PI5Gag-Pol polyprotein 3.4.23.16 0.799
1m0b 0ZQGag-Pol polyprotein 3.4.23.16 0.799
2fxe DR7Gag-Pol polyprotein 3.4.23.16 0.797
1zsf 0ZSGag-Pol polyprotein 3.4.23.16 0.793
1bai 0Q4Gag-Pro polyprotein / 0.792
3eky DR7Gag-Pol polyprotein 3.4.23.16 0.786
1sbg IM1Gag-Pol polyprotein / 0.784
1w5w BE4Gag-Pol polyprotein 3.4.23.16 0.781
3ekw DR7Gag-Pol polyprotein 3.4.23.16 0.780
3kfs 3TLGag-Pol polyprotein / 0.776
1ec2 BEJGag-Pol polyprotein 3.4.23.16 0.775
3el1 DR7Gag-Pol polyprotein 3.4.23.16 0.774
4k4p 3TLGag-Pol polyprotein / 0.774
1hvj A78Gag-Pol polyprotein / 0.771
2qci 065Gag-Pol polyprotein 3.4.23.16 0.771
3toh 079Gag-Pol polyprotein 2.7.7.49 0.771
2fxd DR7Pol polyprotein / 0.769
1n49 RITGag-Pol polyprotein 3.4.23.16 0.768
2wkz 5AHGag-Pol polyprotein / 0.768
4hdf G52Gag-Pol polyprotein 3.4.23.16 0.767
1a8k 0Q4Gag-Pol polyprotein 3.4.23.16 0.766
2qd6 065Gag-Pol polyprotein 3.4.23.16 0.766
3el9 DR7Gag-Pol polyprotein 3.4.23.16 0.763
3tof 076Gag-Pol polyprotein 2.7.7.49 0.759
3sa9 A68Protease / 0.758
1zj7 0ZTGag-Pol polyprotein 3.4.23.16 0.753
1ec3 MS3Gag-Pol polyprotein 3.4.23.16 0.752
3slz 3TLPutative gag-pro-pol polyprotein / 0.751
1hvk A79Gag-Pol polyprotein / 0.750
1tcx IM1Gag-Pol polyprotein 3.4.23.16 0.750
1hvs A77Gag-Pol polyprotein / 0.749
1hih C20Gag-Pol polyprotein / 0.747
1z1h HBBGag-Pol polyprotein 3.4.23.16 0.747
2uy0 HV1Gag-Pol polyprotein 3.4.23.16 0.747
3o9c K20Pol polyprotein / 0.747
1z1r HBHGag-Pol polyprotein 3.4.23.16 0.746
3cyw 017Gag-Pol polyprotein 3.4.23.16 0.744
1bdq IM1Gag-Pol polyprotein 3.4.23.16 0.741
2p3a 3TLPol protein / 0.739
1eby BEBGag-Pol polyprotein 3.4.23.16 0.738
4heg G52Gag-Pol polyprotein 3.4.23.16 0.737
1ody LP1Gag-Pol polyprotein 3.4.23.16 0.734
4hdb G52Gag-Pol polyprotein 3.4.23.16 0.734
1b6p PI7Gag-Pol polyprotein 3.4.23.16 0.733
2pk6 O33V-1 protease / 0.732
2q54 MU1Protease / 0.732
3lzu 017Gag-Pol polyprotein 3.4.23.16 0.732
1hsg MK1Gag-Pol polyprotein / 0.731
2p3b 3TLV-1 PROTEASE protein / 0.731
2p3b 3TLV-1 protease / 0.731
4kb9 G79Protease / 0.731
2f81 017Gag-Pol polyprotein 3.4.23.16 0.730
3zpu M8BGag-Pol polyprotein 3.4.23.16 0.730
2aqu DR7Gag-Pol polyprotein 3.4.23.16 0.729
2qi5 MZ7Gag-Pol polyprotein / 0.729
3sa3 23XProtease / 0.729
1ebk 0Q4Gag-Pol polyprotein 3.4.23.16 0.728
1wbm BLLPol protein / 0.726
1mrw K57Gag-Pol polyprotein 3.4.23.16 0.725
2ieo 017Protease / 0.724
2qd8 065Gag-Pol polyprotein 3.4.23.16 0.724
2xye CXGGag-Pol polyprotein / 0.724
1w5x BE5Gag-Pol polyprotein 3.4.23.16 0.723
3ndt ROCGag-Pol polyprotein 3.4.23.16 0.722
2b60 RITPol polyprotein / 0.721
2uxz HI1Gag-Pol polyprotein 3.4.23.16 0.721
3o9a K14Pol polyprotein / 0.721
3ok9 G52Gag-Pol polyprotein 3.4.23.16 0.721
1hos PHPGag-Pol polyprotein / 0.720
4hdp G52Gag-Pol polyprotein 3.4.23.16 0.720
1msn JE2Gag-Pol polyprotein 3.4.23.16 0.718
4dqc 017Gag-Pol polyprotein / 0.718
1bdr IM1Gag-Pol polyprotein 3.4.23.16 0.717
3el4 ROCGag-Pol polyprotein 3.4.23.16 0.717
1hxw RITGag-Pol polyprotein / 0.716
2i4d QFIProtease / 0.716
1d4h BEHGag-Pol polyprotein 3.4.23.16 0.715
1ebz BECGag-Pol polyprotein 3.4.23.16 0.715
3ekt 017Gag-Pol polyprotein 3.4.23.16 0.715
3pwr ROCGag-Pol polyprotein 3.4.23.16 0.715
3uhl 2NCGag-Pol polyprotein 3.4.23.16 0.714
4njv RITProtease / 0.714
1dif A85Gag-Pol polyprotein / 0.713
3mws 017Pol protein / 0.713
3st5 G89Gag-Pol polyprotein 3.4.23.16 0.712
1hvi A77Protease / 0.711
1sdu MK1Gag-Pol polyprotein 3.4.23.16 0.711
1sh9 RITGag-Pol polyprotein 3.4.23.16 0.711
3s85 LK0Gag-Pol polyprotein / 0.711
3tog 079Gag-Pol polyprotein 2.7.7.49 0.711
2p3d 3TLProtease / 0.710
1hiv 1ZKGag-Pol polyprotein / 0.709
2nmy ROCProtease / 0.709
2z4o 065Gag-Pol polyprotein 3.4.23.16 0.709
3d20 017Gag-Pol polyprotein 3.4.23.16 0.709
4i8z G08Gag-Pol polyprotein 3.4.23.16 0.709
1hii C20Gag-Pol polyprotein / 0.708
1sdv MK1Gag-Pol polyprotein 3.4.23.16 0.708
2cen 4AHProtease / 0.708
2fle AIProtease / 0.708
3d1z 017Gag-Pol polyprotein 3.4.23.16 0.708
3ndx RITGag-Pol polyprotein 3.4.23.16 0.708
1hpx KNIGag-Pol polyprotein / 0.707
2p3c 3TLProtease / 0.707
3ggx GGXGag-Pol polyprotein / 0.706
3oy4 017Gag-Pol polyprotein 3.4.23.16 0.706
9hvp 0E9Gag-Pol polyprotein / 0.706
2bbb HH1Gag-Pol polyprotein 3.4.23.16 0.705
2bqv A1AProtease / 0.705
3nls 016Gag-Pol polyprotein 3.4.23.16 0.705
2bpv 1INGag-Pol polyprotein 3.4.23.16 0.704
2xyf G40Gag-Pol polyprotein / 0.704
4a4q UX9Pol protein / 0.704
4a6c QG9Gag-Pol polyprotein 3.4.23.16 0.703
2f80 017Gag-Pol polyprotein 3.4.23.16 0.702
3ekx 1UNGag-Pol polyprotein 3.4.23.16 0.702
1d4l PI9Gag-Pol polyprotein 3.4.23.16 0.701
2qd7 065Gag-Pol polyprotein 3.4.23.16 0.701
1w5v BE3Gag-Pol polyprotein 3.4.23.16 0.700
2i4u DJRProtease / 0.698
1fmb HYBPol polyprotein / 0.697
2hs2 017Protease / 0.697
1vij BAYGag-Pol polyprotein / 0.696
2q55 MU0Protease / 0.696
2pyn 1UNGag-Pol polyprotein 3.4.23.16 0.695
4dqe 017Gag-Pol polyprotein / 0.695
1siv PSIGag-Pol polyprotein / 0.694
3kfp 3TLGag-Pol polyprotein / 0.694
2ien 017Gag-Pol polyprotein 3.4.23.16 0.691
3jvy 017Gag-Pol polyprotein 3.4.23.16 0.691
3em3 478Gag-Pol polyprotein 3.4.23.16 0.690
3ndw RITGag-Pol polyprotein 3.4.23.16 0.690
3qaa G04Gag-Pol polyprotein 3.4.23.16 0.690
1d4i BEGGag-Pol polyprotein 3.4.23.16 0.688
1mrx K57Gag-Pol polyprotein 3.4.23.16 0.688
4djo MK5Pol polyprotein / 0.688
4njt 017Protease / 0.688
1mtr PI6Gag-Pol polyprotein 3.4.23.16 0.686
2nnk ROCProtease / 0.686
3o9e A60Pol polyprotein / 0.686
3zpt M8YGag-Pol polyprotein 3.4.23.16 0.686
1t7j 478Gag-Pol polyprotein 3.4.23.16 0.685
3nu6 478Gag-Pol polyprotein 3.4.23.16 0.685
3nu9 478Gag-Pol polyprotein 3.4.23.16 0.683
3tl9 ROCGag-Pol polyprotein 3.4.23.16 0.683
1zsr 0ZTGag-Pol polyprotein 3.4.23.16 0.682
3zps EQMGag-Pol polyprotein 3.4.23.16 0.682
4qgi ROCGag-Pol polyprotein 3.4.23.16 0.682
3jw2 017Gag-Pol polyprotein 3.4.23.16 0.681
1hpv 478Gag-Pol polyprotein / 0.680
2hb3 GRLProtease / 0.680
2nnp ROCProtease / 0.680
2wl0 5AHGag-Pol polyprotein / 0.680
3ec0 GRLGag-Pol polyprotein 3.4.23.47 0.680
1a8g 2Z4Gag-Pol polyprotein 3.4.23.16 0.679
1ec0 BEDGag-Pol polyprotein 3.4.23.16 0.679
2pym 1UNGag-Pol polyprotein 3.4.23.16 0.679
2r38 G4GGag-Pol polyprotein 3.4.23.16 0.679
3bxs DRSGag-Pol polyprotein 3.4.23.16 0.679
3s56 ROCProtease / 0.679
2fdd 385Pol protein / 0.678
1d4j MSCGag-Pol polyprotein 3.4.23.16 0.677
3dk1 G05Gag-Pol polyprotein 3.4.23.16 0.677
2z54 AB1Gag-Pol polyprotein 3.4.23.16 0.676
4dfg 0JVGag-Pol polyprotein 3.4.23.16 0.676
4djq M86Pol polyprotein / 0.676
4j54 G52Gag-Pol polyprotein 3.4.23.16 0.676
1b11 3TLPol polyprotein / 0.675
1ebw BEIGag-Pol polyprotein 3.4.23.16 0.675
1npa 3NHGag-Pol polyprotein 3.4.23.16 0.675
1npw LGZGag-Pol polyprotein 3.4.23.16 0.675
2i0d MUTProtease / 0.675
2cej 1AHPol protein / 0.674
3bvb 017Gag-Pol polyprotein 3.4.23.16 0.674
3o9b K2APol polyprotein / 0.674
1t7i 017Gag-Pol polyprotein 3.4.23.16 0.673
3i6o GR6Gag-Pol polyprotein 3.4.23.16 0.673
3vfb 031Gag-Pol polyprotein 3.4.23.16 0.673
4njs G08Protease / 0.673
2a4f AAUV-1 protease / 0.671
3el5 1UNGag-Pol polyprotein / 0.671
3gi4 K60Gag-Pol polyprotein / 0.671
2i0a MUIProtease / 0.670
3lzs 017Gag-Pol polyprotein 3.4.23.16 0.670
3vf7 031Gag-Pol polyprotein 3.4.23.16 0.670
3vf5 031Gag-Pol polyprotein 3.4.23.16 0.668
1b6m PI6Gag-Pol polyprotein 3.4.23.16 0.667
3lin E13Protease / 0.667
1b6l PI4Gag-Pol polyprotein 3.4.23.16 0.666
3sa5 A69Protease / 0.666
4djp M73Pol polyprotein / 0.666
2avv MK1Gag-Pol polyprotein 3.4.23.16 0.665
3ekv 478Gag-Pol polyprotein 3.4.23.16 0.665
3sab F78Protease / 0.665
1c70 L75Protease / 0.664
1vik BAYGag-Pol polyprotein / 0.664
3nuo 478Gag-Pol polyprotein 3.4.23.16 0.664
1a9m U0EGag-Pol polyprotein / 0.663
2hs1 017Protease / 0.663
3ucb 017Gag-Pol polyprotein / 0.663
1c6x 3INProtease / 0.662
1w5y BE6Gag-Pol polyprotein 3.4.23.16 0.662
3ggu 017Gag-Pol polyprotein 3.4.23.16 0.662
3d1x ROCGag-Pol polyprotein 3.4.23.16 0.661
3ecg 065Gag-Pol polyprotein 3.4.23.47 0.660
2fmb LP1Reverse transcriptase / 0.658
3o9f K2DGag-Pol polyprotein / 0.658
3o9g F53Gag-Pol polyprotein / 0.658
3ixj 586Beta-secretase 1 3.4.23.46 0.657
3mxd K53Gag-Pol polyprotein 3.4.23.16 0.657
1d4k PI8Gag-Pol polyprotein 3.4.23.16 0.656
4q1w 017Gag-Pol polyprotein 3.4.23.16 0.656
1t3r 017Gag-Pol polyprotein 3.4.23.16 0.655
2q5k AB1Protease / 0.655
3i7e DJRGag-Pol polyprotein / 0.655
4ye3 G04Gag-Pol polyprotein 3.4.23.16 0.655
1ppl 1Z7Penicillopepsin-1 3.4.23.20 0.654
3ekq ROCGag-Pol polyprotein 3.4.23.16 0.654
3pwm 017Gag-Pol polyprotein 3.4.23.16 0.654
3s54 017Protease / 0.654
3vfa 031Gag-Pol polyprotein 3.4.23.16 0.654
4q1x 017Gag-Pol polyprotein 3.4.23.16 0.654
3bgc LJHGag-Pol polyprotein 3.4.23.16 0.653
3cyx ROCGag-Pol polyprotein 3.4.23.16 0.653
3oxw 017Gag-Pol polyprotein 3.4.23.16 0.653
3tlh 3TLGag-Pol polyprotein 3.4.23.16 0.653
2qi0 MZ3Gag-Pol polyprotein / 0.652
2rkf AB1Pol protein / 0.652
3djk G55Gag-Pol polyprotein 3.4.23.16 0.652
4q1y 017Gag-Pol polyprotein 3.4.23.16 0.652
1k6p XN3Gag-Pol polyprotein 3.4.23.16 0.651
2f3k RO1Protease / 0.651
2qhc AB1Protease / 0.650
3ekp 478Gag-Pol polyprotein 3.4.23.16 0.650
3fx5 KNIGag-Pol polyprotein 3.4.23.16 0.650