Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1esn ANP Pantothenate kinase 2.7.1.33

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1esn ANPPantothenate kinase 2.7.1.33 1.022
5l3s GNPSignal recognition particle receptor FtsY / 0.838
2jiz ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.812
1w5t ANPORC1-type DNA replication protein 2 / 0.808
2j0s ANPEukaryotic initiation factor 4A-III 3.6.4.13 0.808
3q9l ATPSeptum site-determining protein MinD / 0.808
4xvu ATPATPase GET3 / 0.807
1nsf ATPVesicle-fusing ATPase 3.6.4.6 0.802
2j7p GNPSignal recognition particle protein / 0.802
2j7p GNPSignal recognition particle receptor FtsY / 0.802
4dsn GCPGTPase KRas / 0.800
4idn GNPAtlastin-1 3.6.5 0.790
1q3h ANPCystic fibrosis transmembrane conductance regulator / 0.789
2jlr ANPGenome polyprotein 3.4.21.91 0.778
1gqy ACPUDP-N-acetylmuramate--L-alanine ligase 6.3.2.8 0.777
5jlj GNPGTP-binding nuclear protein Ran / 0.774
1rj9 GCPSignal recognition particle receptor FtsY / 0.772
2jj2 ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.765
1bmf ANPATP synthase subunit alpha, mitochondrial / 0.763
1bmf ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.763
4c0b ATPmRNA cleavage and polyadenylation factor CLP1 / 0.763
4db1 ANPMyosin-7 / 0.763
4hdq GNPRas-related protein Rap-1b / 0.762
4v02 ATPSite-determining protein / 0.762
1s1c GNPTransforming protein RhoA / 0.759
3i3s GNPGTPase HRas / 0.759
3rs4 GNPGTPase HRas / 0.759
3rs5 GNPGTPase HRas / 0.759
3k9l GNPGTPase HRas / 0.758
3v4f GNPGTPase HRas / 0.758
1oix GDPRas-related protein Rab-11A / 0.756
1p3d ANPUDP-N-acetylmuramate--L-alanine ligase 6.3.2.8 0.753
3myk ANPMyosin-2 heavy chain / 0.752
3rab GNPRas-related protein Rab-3A / 0.752
3zfd ANPChromosome-associated kinesin KIF4 / 0.751
2c5l GTPGTPase HRas / 0.750
1azt GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.749
3tgp GNPGTPase HRas / 0.747
3oiw GNPGTPase HRas / 0.745
2rgg GNPGTPase HRas / 0.744
3k8y GNPGTPase HRas / 0.744
3oiu GNPGTPase HRas / 0.744
3oiv GNPGTPase HRas / 0.744
3rs0 GNPGTPase HRas / 0.744
4dls GNPGTPase HRas / 0.744
3x1z GNPRas-related protein Rap-1b / 0.743
4l9w GNPGTPase HRas / 0.743
4xvq GNPGTPase HRas / 0.743
2qme GCPRas-related C3 botulinum toxin substrate 3 / 0.742
3oes GNPGTPase RhebL1 / 0.742
4dlx GNPGTPase HRas / 0.742
1ky2 GNPGTP-binding protein YPT7 / 0.741
2rgc GNPGTPase HRas / 0.741
4be7 ATPType I restriction enzyme EcoR124II R protein 3.1.21.3 0.741
2bme GNPRas-related protein Rab-4A / 0.740
2cl6 CAGGTPase HRas / 0.739
1yu9 GNPRas-related protein Rab-4A / 0.738
3oee ANPATP synthase subunit alpha, mitochondrial / 0.738
3oee ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.738
3x1w GDPRas-related protein Rap-1b / 0.737
4epx GDPGTPase KRas / 0.735
1uad GNPRas-related protein Ral-A / 0.732
2fg5 GNPRas-related protein Rab-31 / 0.732
2ck3 ANPATP synthase subunit alpha, mitochondrial / 0.731
2ck3 ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.731
4cvm ANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase / 0.731
4dlv GNPGTPase HRas / 0.731
1ii6 ADPKinesin-like protein KIF11 / 0.728
3zia ATPATP synthase subunit alpha, mitochondrial / 0.728
4lhw GNPRas-related protein Rab-8A / 0.728
3tso GNPRas-related protein Rab-25 / 0.727
2bc9 GNPGuanylate-binding protein 1 / 0.726
4hdo GNPRas-related protein Rap-1b / 0.726
1g17 GNPRas-related protein SEC4 / 0.725
1vg8 GNPRas-related protein Rab-7a / 0.725
3l8y GNPGTPase HRas / 0.724
4bec ATPType I restriction enzyme EcoR124II R protein 3.1.21.3 0.724
4l8g GDPGTPase KRas / 0.724
4wa7 GDPGTPase KRas / 0.724
2qtv GNPSmall COPII coat GTPase SAR1 3.6.5 0.723
4epw GDPGTPase KRas / 0.722
4ki0 ANPMaltose/maltodextrin import ATP-binding protein MalK / 0.722
4ohv ANPProtein clpf-1 / 0.722
4tq9 GDPGTPase KRas / 0.722
1fmw ATPMyosin-2 heavy chain / 0.721
4lpk GDPGTPase KRas / 0.721
1z0d GDPRas-related protein Rab-5C / 0.720
3wyg GTPGTP-binding nuclear protein GSP1/CNR1 / 0.720
1jx2 ADPMyosin-2 heavy chain / 0.719
2xae ADPKinesin-like protein KIF11 / 0.719
3oeh ANPATP synthase subunit alpha, mitochondrial / 0.719
4dsu GDPGTPase KRas / 0.718
1h8h ATPATP synthase subunit alpha, mitochondrial / 0.717
1h8h ATPATP synthase subunit beta, mitochondrial 3.6.3.14 0.717
2fgj ATPAlpha-hemolysin translocation ATP-binding protein HlyB / 0.717
2hld ANPATP synthase subunit alpha, mitochondrial / 0.717
2hld ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.717
1sq5 ADPPantothenate kinase 2.7.1.33 0.716
3e5h GNPRas-related protein Rab-28 / 0.716
4nh0 ATPESX secretion system protein EccC / 0.715
4dlw GNPGTPase HRas / 0.714
1z6t ADPApoptotic protease-activating factor 1 / 0.713
3pit GNPRas-related protein M-Ras / 0.713
4rkf GNPRas-related protein Rab-3 / 0.713
1ibr GNPGTP-binding nuclear protein Ran / 0.712
2y65 ADPKinesin heavy chain / 0.712
4dlz GNPGTPase HRas / 0.712
1cul GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.711
2l0x GDPGTP-binding protein Rheb / 0.711
2uyi ADPKinesin-like protein KIF11 / 0.711
2x2r ADPKinesin-like protein KIF11 / 0.711
5dif GNPGTP-binding nuclear protein Ran / 0.711
1xtr GNPGTP-binding protein Rheb / 0.710
4luc GDPGTPase KRas / 0.710
1d5c GDPGTPase (Rab6) / 0.709
1zd9 GDPADP-ribosylation factor-like protein 8A / 0.709
3a58 GNPGTP-binding protein RHO1 / 0.709
3kud GDPGTPase HRas / 0.709
4tl6 ANPCircadian clock protein kinase KaiC 2.7.11.1 0.709
4xjx ATPType I restriction enzyme EcoR124II R protein 3.1.21.3 0.709
1e1q ANPATP synthase subunit alpha, mitochondrial / 0.707
1e1q ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.707
1khe GCPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.706
1rrg GDPADP-ribosylation factor 1 / 0.706
2qen ADPWalker-Type ATPase / 0.706
3q5d GDPAtlastin-1 3.6.5 0.706
1khb GCPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.705
1z0f GDPRas-related protein Rab-14 / 0.705
4pao GSPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.705
1lfd GNPGTPase HRas / 0.704
3mjh GTPRas-related protein Rab-5A / 0.703
5ftc ADPTPR domain protein / 0.703
2oap ANPType II secretion system protein (GspE-2) / 0.702
2v7q ATPATP synthase subunit alpha, mitochondrial / 0.701
2v7q ATPATP synthase subunit beta, mitochondrial 3.6.3.14 0.701
4cym GCPRas-related protein Rab-32 / 0.700
1fp6 ADPNitrogenase iron protein 1 1.18.6.1 0.699
2a5y ATPCell death protein 4 / 0.698
2q3f GNPRas-related GTP-binding protein D / 0.696
5cyo GDPSeptin-9 / 0.696
1njf ADPDNA polymerase III subunit tau 2.7.7.7 0.694
3cx8 GSPGuanine nucleotide-binding protein subunit alpha-13 / 0.693
3ref GDPRho family GTPase / 0.693
1svw GTPProbable GTP-binding protein EngB / 0.692
4dso GSPGTPase KRas / 0.692
1k5d GNPGTP-binding nuclear protein Ran / 0.691
3vx4 ATPPutative ABC transporter, ATP-binding protein ComA / 0.691
4mkf AP5Adenylate kinase / 0.691
2ce2 GDPGTPase HRas / 0.690
2ic5 GDPRas-related C3 botulinum toxin substrate 3 / 0.690
4tnr DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.690
1h65 GDPTranslocase of chloroplast 34 3.6.5 0.689
1wa5 GTPGTP-binding nuclear protein Ran / 0.689
2iut AGSDNA translocase FtsK / 0.689
3kuc GDPRas-related protein Rap-1A / 0.689
4o2r GDPGTP-binding protein Rheb / 0.689
1oyy AGSATP-dependent DNA helicase RecQ 3.6.4.12 0.688
1w7k ADPDihydrofolate synthase/folylpolyglutamate synthase 6.3.2.12 0.688
3tkl GTPRas-related protein Rab-1A / 0.688
5c46 GSPRas-related protein Rab-11A / 0.688
1gp2 GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.687
2dwp ACP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 2.7.1.105 0.687
3adc ANPL-seryl-tRNA(Sec) kinase 2.7.1.164 0.687
4c2u ANPDNA helicase / 0.686
4qxa GTPRas-related protein Rab-9A / 0.685
4tl8 AGSCircadian clock protein kinase KaiC 2.7.11.1 0.685
4wou GDPPhosphoenolpyruvate carboxykinase [GTP] / 0.685
1got GDPGuanine nucleotide-binding protein G(t) subunit alpha-1 / 0.684
1yra GDPGPN-loop GTPase PAB0955 / 0.684
3kko GNPRas-related protein M-Ras / 0.684
3t1t GDPProbable gliding protein mglA / 0.684
3vhx GTPADP-ribosylation factor 6 / 0.684
3r9x GNPGTPase Era / 0.683
4cid ANPEH domain-containing protein 2 / 0.683
4jl6 ADPAdenylate kinase / 0.683
1loo GTPAdenylosuccinate synthetase isozyme 1 / 0.682
1mma ADPMyosin-2 heavy chain / 0.682
2ql6 ADPNicotinamide riboside kinase 1 / 0.682
1ohh ANPATP synthase subunit alpha, mitochondrial / 0.681
1ohh ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.681
4qbf AP5Adenylate kinase / 0.681
2xtn GTPGTPase IMAP family member 2 / 0.680
5k5z ANPUncharacterized protein / 0.680
2gqr ADPPhosphoribosylaminoimidazole-succinocarboxamide synthase 6.3.2.6 0.679
4qm6 GTPMetallophosphoesterase / 0.679
1e4v AP5Adenylate kinase / 0.678
1ank ANPAdenylate kinase / 0.677
1h8h ADPATP synthase subunit alpha, mitochondrial / 0.677
1h8h ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.677
1v8k ANPKinesin-like protein KIF2C / 0.677
4cei ANPATP-dependent helicase/deoxyribonuclease subunit B 3.1 0.677
4gzm GSPRas-related C3 botulinum toxin substrate 1 / 0.676
1fnn ADPORC1-type DNA replication protein / 0.675
3l1c ADPProtein claret segregational / 0.675
3o0n TTPVitamin B12-dependent ribonucleotide reductase / 0.675
4dem YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.675
1ayl ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.674
1g16 GDPRas-related protein SEC4 / 0.674
1xnj ADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.7.1.25 0.673
2dpx GDPGTP-binding protein RAD / 0.673
4tle AGSCircadian clock protein kinase KaiC 2.7.11.1 0.673
2g1q ADPKinesin-like protein KIF11 / 0.672
2ffq GSPRas-related protein Rab-6B / 0.671
4x8l AP5Adenylate kinase / 0.671
1svl ADPLarge T antigen 3.6.4 0.670
1yrs ADPKinesin-like protein KIF11 / 0.670
1ytm ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.670
3ryw K9HFarnesyl pyrophosphate synthase, putative / 0.670
4h5d YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.670
3fvq ATPFe(3+) ions import ATP-binding protein FbpC / 0.669
2c96 ATPPsp operon transcriptional activator / 0.668
4jsy GTPMetallophosphoesterase / 0.668
2vf7 ADPUvrABC system protein A / 0.667
2w2v GTPRas-related C3 botulinum toxin substrate 2 / 0.667
2zr9 DTPProtein RecA / 0.667
1tfz 8694-hydroxyphenylpyruvate dioxygenase 1.13.11.27 0.666
1z0a GDPRas-related protein Rab-2A / 0.666
1njf AGSDNA polymerase III subunit tau 2.7.7.7 0.665
3hu1 AGSTransitional endoplasmic reticulum ATPase 3.6.4.6 0.665
2qf2 GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.664
2y6d TQJMatrilysin 3.4.24.23 0.664
3a6p GTPGTP-binding nuclear protein Ran / 0.664
4yqf GDPSeptin-9 / 0.664
1j7k ATPHolliday junction ATP-dependent DNA helicase RuvB / 0.663
2bku GTPGTP-binding nuclear protein Ran / 0.663
3qcz ANPDihydrofolate synthase/folylpolyglutamate synthase / 0.663
4ko8 AGSTransitional endoplasmic reticulum ATPase 3.6.4.6 0.663
1nly AGSCag alpha / 0.662
2w2x GSPRas-related C3 botulinum toxin substrate 2 / 0.662
1tg5 6454-hydroxyphenylpyruvate dioxygenase 1.13.11.27 0.661
3b05 IPEIsopentenyl-diphosphate delta-isomerase / 0.661
3fgo CZASarcoplasmic/endoplasmic reticulum calcium ATPase 1 3.6.3.8 0.661
4cvl ACPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase / 0.661
4ol0 GTPGTP-binding nuclear protein Ran / 0.661
1sa4 JANProtein farnesyltransferase subunit beta 2.5.1.58 0.660
2f0y 3MNProtein farnesyltransferase subunit beta 2.5.1.58 0.660
3k14 5352-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase / 0.660
3ksq Z96Protein farnesyltransferase subunit beta 2.5.1.58 0.660
3o3j BB4Peptide deformylase 1B, chloroplastic/mitochondrial 3.5.1.88 0.660
3sfx JANUncharacterized protein / 0.660
3tjz GNPADP-ribosylation factor 1 / 0.660
3znr NU9Histone deacetylase 7 3.5.1.98 0.660
4bzq ADPBifunctional enzyme CysN/CysC 2.7.1.25 0.660
4gtp 7TPProtein farnesyltransferase subunit beta 2.5.1.58 0.660
4lnb ED5CaaX farnesyltransferase beta subunit Ram1 / 0.660
4lng JANCaaX farnesyltransferase beta subunit Ram1 / 0.660
4tl9 AGSCircadian clock protein kinase KaiC 2.7.11.1 0.660
5kcp PFBAlcohol dehydrogenase E chain 1.1.1.1 0.660
4ag5 ADPType IV secretory pathway VirB4 components-like protein / 0.659
4h5e YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.659
1y3a GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.658
3hu2 AGSTransitional endoplasmic reticulum ATPase 3.6.4.6 0.658
4qnr ATPPsp operon transcriptional activator / 0.658
4zir ANPEnergy-coupling factor transporter ATP-binding protein EcfA2 3.6.3 0.658
4zir ANPEnergy-coupling factor transporter ATP-binding protein EcfA1 / 0.658
1pl6 572Sorbitol dehydrogenase 1.1.1.14 0.657
5cto NTD4-hydroxyphenylpyruvate dioxygenase 1.13.11.27 0.655
1n6m ADPProtein claret segregational / 0.654
1ny5 ADPTranscriptional regulator (NtrC family) / 0.654
1t47 NTD4-hydroxyphenylpyruvate dioxygenase 1.13.11.27 0.654
3hpr AP5Adenylate kinase / 0.654
3w3z GTPGTP-binding nuclear protein Ran / 0.654
2ji7 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.653
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.653
3hpq AP5Adenylate kinase / 0.653
4jl5 ADPAdenylate kinase / 0.653
2c31 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.652
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.652
2q0c CTPPoly(A) polymerase, putative / 0.651
4o2l GTPGTP-binding protein Rheb / 0.651
2ywv ADPPhosphoribosylaminoimidazole-succinocarboxamide synthase / 0.650
3pcn DHYProtocatechuate 3,4-dioxygenase alpha chain 1.13.11.3 0.650
3pcn DHYProtocatechuate 3,4-dioxygenase beta chain 1.13.11.3 0.650
4bzc T8TDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.650
4nke RISFarnesyl pyrophosphate synthase 2.5.1.10 0.650