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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1efl NAD NAD-dependent malic enzyme, mitochondrial 1.1.1.38

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1efl NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 1.091
1pj3 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 1.027
1do8 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 1.025
1pj2 NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.974
1gq2 NAPNADP-dependent malic enzyme 1.1.1.40 0.906
1efk NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.904
1qr6 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.835
1gz4 ATPNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.762
1pj4 ATPNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.750
1llq NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.736
4nu6 NADPhosphonate dehydrogenase 1.20.1.1 0.707
1o0s NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.700
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.686
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.686
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.685
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.679
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.664
4k28 NADShikimate dehydrogenase family protein / 0.662
3t4e NADQuinate/shikimate dehydrogenase / 0.659
3cea NADMyo-inositol 2-dehydrogenase-like (Promiscuous) / 0.657
1ky4 NADAdenosylhomocysteinase 3.3.1.1 0.654
1npd NADQuinate/shikimate dehydrogenase / 0.653
1b3r NADAdenosylhomocysteinase 3.3.1.1 0.650
3d64 NADAdenosylhomocysteinase / 0.650