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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1e81 M91 Endothiapepsin 3.4.23.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1e81 M91Endothiapepsin 3.4.23.22 1.301
1od1 0QSEndothiapepsin 3.4.23.22 0.965
1e82 M90Endothiapepsin 3.4.23.22 0.961
2jjj 0QSEndothiapepsin 3.4.23.22 0.957
2jji 0QSEndothiapepsin 3.4.23.22 0.943
1gvt 2ZSEndothiapepsin 3.4.23.22 0.854
1e80 0GQEndothiapepsin 3.4.23.22 0.834
1gvv 0GMEndothiapepsin 3.4.23.22 0.824
1gvw 0EMEndothiapepsin 3.4.23.22 0.816
1bxq PP8Penicillopepsin-1 3.4.23.20 0.814
1bxo PP7Penicillopepsin-1 3.4.23.20 0.804
1ppk IVVPenicillopepsin-1 3.4.23.20 0.782
1ppl 1Z7Penicillopepsin-1 3.4.23.20 0.762
3d91 REMRenin 3.4.23.15 0.750
2web PP4Penicillopepsin-1 3.4.23.20 0.734
1ppm 0P1Penicillopepsin-1 3.4.23.20 0.733
3prs RITEndothiapepsin 3.4.23.22 0.732
1zap A70Candidapepsin-2 3.4.23.24 0.727
1psa 0ZLPepsin A 3.4.23.1 0.720
1rne C60Renin 3.4.23.15 0.709
3own 3OXRenin 3.4.23.15 0.699
3duy AFJBeta-secretase 1 3.4.23.46 0.695
2g94 ZPQBeta-secretase 1 3.4.23.46 0.688
3k5g BJCBeta-secretase 1 3.4.23.46 0.688
3veu 0GOBeta-secretase 1 3.4.23.46 0.688
1qrp HH0Pepsin A-4 3.4.23.1 0.685
3pww ROCEndothiapepsin 3.4.23.22 0.684
1xe5 5FEPlasmepsin-2 3.4.23.39 0.681
1eag A70Candidapepsin-2 3.4.23.24 0.680
3r2f PB0Beta-secretase 1 3.4.23.46 0.679
3dv5 BAVBeta-secretase 1 3.4.23.46 0.677
3k5d XLIBeta-secretase 1 3.4.23.46 0.673
2p4j 23IBeta-secretase 1 3.4.23.46 0.662
2qzl IXSBeta-secretase 1 3.4.23.46 0.653
1w51 L01Beta-secretase 1 3.4.23.46 0.652
1w6h TITPlasmepsin-2 3.4.23.39 0.652
3q70 RITCandidapepsin-2 3.4.23.24 0.652
2wf2 ZY2Beta-secretase 1 3.4.23.46 0.650