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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1e80 0GQ Endothiapepsin 3.4.23.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1e80 0GQEndothiapepsin 3.4.23.22 1.338
2jjj 0QSEndothiapepsin 3.4.23.22 0.934
2jji 0QSEndothiapepsin 3.4.23.22 0.912
1od1 0QSEndothiapepsin 3.4.23.22 0.898
1gvw 0EMEndothiapepsin 3.4.23.22 0.889
1gvv 0GMEndothiapepsin 3.4.23.22 0.849
1e81 M91Endothiapepsin 3.4.23.22 0.834
1gvt 2ZSEndothiapepsin 3.4.23.22 0.800
1e82 M90Endothiapepsin 3.4.23.22 0.790
1bil 0IURenin 3.4.23.15 0.765
3cid 318Beta-secretase 1 3.4.23.46 0.761
1eag A70Candidapepsin-2 3.4.23.24 0.742
3d91 REMRenin 3.4.23.15 0.740
4exg 916Beta-secretase 1 3.4.23.46 0.726
1w6h TITPlasmepsin-2 3.4.23.39 0.723
1ppk IVVPenicillopepsin-1 3.4.23.20 0.722
4ewo 996Beta-secretase 1 3.4.23.46 0.722
4dus 0MPBeta-secretase 1 3.4.23.46 0.720
2iqg F2IBeta-secretase 1 3.4.23.46 0.717
2p83 MR0Beta-secretase 1 3.4.23.46 0.717
3lpj Z75Beta-secretase 1 3.4.23.46 0.716
3cib 314Beta-secretase 1 3.4.23.46 0.712
1psa 0ZLPepsin A 3.4.23.1 0.711
2qzl IXSBeta-secretase 1 3.4.23.46 0.706
4ke0 1R8Beta-secretase 1 3.4.23.46 0.706
1zap A70Candidapepsin-2 3.4.23.24 0.702
3qi1 C6ABeta-secretase 1 3.4.23.46 0.702
4k8s 1QTBeta-secretase 1 3.4.23.46 0.702
3nsh 957Beta-secretase 1 3.4.23.46 0.701
4i0i 957Beta-secretase 1 3.4.23.46 0.701
2wf2 ZY2Beta-secretase 1 3.4.23.46 0.700
3k5f AYHBeta-secretase 1 3.4.23.46 0.700
1bim 0QBRenin 3.4.23.15 0.695
1xe6 5FPPlasmepsin-2 3.4.23.39 0.695
2viy VG3Beta-secretase 1 3.4.23.46 0.694
1rne C60Renin 3.4.23.15 0.691
3dv1 AR9Beta-secretase 1 3.4.23.46 0.691
1ppl 1Z7Penicillopepsin-1 3.4.23.20 0.690
2xfi XFIBeta-secretase 1 3.4.23.46 0.690
2xfj VG5Beta-secretase 1 3.4.23.46 0.690
2xfk AA9Beta-secretase 1 3.4.23.46 0.689
3own 3OXRenin 3.4.23.15 0.687
2f3e AXQBeta-secretase 1 3.4.23.46 0.686
2viz VG4Beta-secretase 1 3.4.23.46 0.684
4k9h 1QUBeta-secretase 1 3.4.23.46 0.684
3k5g BJCBeta-secretase 1 3.4.23.46 0.683
4i0j 842Beta-secretase 1 3.4.23.46 0.682
2p8h MY9Beta-secretase 1 3.4.23.46 0.676
2wf1 ZY1Beta-secretase 1 3.4.23.46 0.676
3dm6 757Beta-secretase 1 3.4.23.46 0.675
4dh6 0KNBeta-secretase 1 3.4.23.46 0.674
2b8v 3BNBeta-secretase 1 3.4.23.46 0.672
2f3f AXFBeta-secretase 1 3.4.23.46 0.672
3n4l 842Beta-secretase 1 3.4.23.46 0.672
2b8l 5HABeta-secretase 1 3.4.23.46 0.671
3ixk 929Beta-secretase 1 3.4.23.46 0.671
2vij C44Beta-secretase 1 3.4.23.46 0.670
3dv5 BAVBeta-secretase 1 3.4.23.46 0.670
4ke1 1R6Beta-secretase 1 3.4.23.46 0.670
3ohf 3HFBeta-secretase 1 3.4.23.46 0.669
4dpi 0N1Beta-secretase 1 3.4.23.46 0.667
1lf2 R37Plasmepsin-2 3.4.23.39 0.665
4lxa 1YSBeta-secretase 1 3.4.23.46 0.663
2wf3 ZY3Beta-secretase 1 3.4.23.46 0.654
1xe5 5FEPlasmepsin-2 3.4.23.39 0.652
3r2f PB0Beta-secretase 1 3.4.23.46 0.651
4lxk 1YTBeta-secretase 1 3.4.23.46 0.650