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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1drh NAP Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1drh NAPDihydrofolate reductase 1.5.1.3 1.238
1rx1 NAPDihydrofolate reductase 1.5.1.3 0.943
3kjs NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.910
4kl9 NDPDihydrofolate reductase 1.5.1.3 0.908
1dg8 NDPDihydrofolate reductase 1.5.1.3 0.888
3clb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.885
5ecc NAPDehydrofolate reductase type I / 0.884
2h2q NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.861
3dg8 NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.841
2cig 1DGDihydrofolate reductase 1.5.1.3 0.831
1ra3 NAPDihydrofolate reductase 1.5.1.3 0.815
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.813
3inv NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.802
3tqa NDPDihydrofolate reductase / 0.798
3kjr NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.797
4m6j NDPDihydrofolate reductase 1.5.1.3 0.783
1j3k NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.761
1dr5 NAPDihydrofolate reductase 1.5.1.3 0.758
8dfr NDPDihydrofolate reductase 1.5.1.3 0.755
1ia1 NDPDihydrofolate reductase 1.5.1.3 0.747
3qls NDPDihydrofolate reductase 1.5.1.3 0.727
1m78 NDPDihydrofolate reductase 1.5.1.3 0.726
2w3b NDPDihydrofolate reductase 1.5.1.3 0.723
3nxx NDPDihydrofolate reductase 1.5.1.3 0.717
1j3j NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.716
2d5n NDPRiboflavin biosynthesis protein RibD 1.1.1.193 0.715
1dr3 TAPDihydrofolate reductase 1.5.1.3 0.712
1dr2 TAPDihydrofolate reductase 1.5.1.3 0.710
3qlr NDPDihydrofolate reductase 1.5.1.3 0.704
1ai9 NDPDihydrofolate reductase 1.5.1.3 0.693
1rx8 NAPDihydrofolate reductase 1.5.1.3 0.692
1rx6 NAPDihydrofolate reductase 1.5.1.3 0.678
1juv NDPDihydrofolate reductase 1.5.1.3 0.666
4ha9 NDP2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase 1.1.1.302 0.666
3d84 NDPDihydrofolate reductase 1.5.1.3 0.660
2o7p NAPRiboflavin biosynthesis protein RibD / 0.657