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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dre MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1dre MTXDihydrofolate reductase 1.5.1.3 1.110
1rh3 MTXDihydrofolate reductase 1.5.1.3 1.047
1dra MTXDihydrofolate reductase 1.5.1.3 0.864
3drc MTXDihydrofolate reductase 1.5.1.3 0.851
5hi6 MTXDihydrofolate reductase / 0.844
1u72 MTXDihydrofolate reductase 1.5.1.3 0.843
3dau MTXDihydrofolate reductase 1.5.1.3 0.843
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.834
3ia4 MTXDihydrofolate reductase / 0.834
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.833
2drc MTXDihydrofolate reductase 1.5.1.3 0.831
4dfr MTXDihydrofolate reductase 1.5.1.3 0.831
3eig MTXDihydrofolate reductase 1.5.1.3 0.829
1df7 MTXDihydrofolate reductase 1.5.1.3 0.828
4p66 MTXDihydrofolate reductase / 0.820
7dfr FOLDihydrofolate reductase 1.5.1.3 0.814
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.812
3dfr MTXDihydrofolate reductase 1.5.1.3 0.812
1ohj COPDihydrofolate reductase 1.5.1.3 0.799
4qi9 MTXDihydrofolate reductase / 0.799
3och 2MXDihydrofolate reductase 1.5.1.3 0.798
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.797
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.795
1dhj MTXDihydrofolate reductase 1.5.1.3 0.790
1tdr MTXDihydrofolate reductase 1.5.1.3 0.787
2qk8 MTXDihydrofolate reductase / 0.787
2zza FOLDihydrofolate reductase / 0.786
4i1n FOLDihydrofolate reductase 1.5.1.3 0.781
1u70 MTXDihydrofolate reductase 1.5.1.3 0.776
4m6k FOLDihydrofolate reductase 1.5.1.3 0.776
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.775
4x5g FOLDihydrofolate reductase 1.5.1.3 0.768
3tq9 MTXDihydrofolate reductase / 0.766
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.763
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.762
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.759
4p68 MTXDihydrofolate reductase / 0.759
1dyh DZFDihydrofolate reductase 1.5.1.3 0.756
4x5f FOLDihydrofolate reductase 1.5.1.3 0.755
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.754
1dls MTXDihydrofolate reductase 1.5.1.3 0.752
1re7 FOLDihydrofolate reductase 1.5.1.3 0.751
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.751
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.750
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.747
4i13 FOLDihydrofolate reductase 1.5.1.3 0.745
1dhi MTXDihydrofolate reductase 1.5.1.3 0.739
3frd DHFDihydrofolate reductase 1.5.1.3 0.737
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.736
1drb MTXDihydrofolate reductase 1.5.1.3 0.735
1ohk COPDihydrofolate reductase 1.5.1.3 0.734
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.733
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.732
4x5h FOLDihydrofolate reductase 1.5.1.3 0.731
1jol FFODihydrofolate reductase 1.5.1.3 0.730
4keb FOLDihydrofolate reductase 1.5.1.3 0.730
1e26 GPBDihydrofolate reductase 1.5.1.3 0.728
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.727
4kjj FOLDihydrofolate reductase 1.5.1.3 0.724
1jom FFODihydrofolate reductase 1.5.1.3 0.723
1drf FOLDihydrofolate reductase 1.5.1.3 0.722
1hfq MOTDihydrofolate reductase 1.5.1.3 0.720
5ccc DDFDihydrofolate reductase 1.5.1.3 0.718
1dyi FOLDihydrofolate reductase 1.5.1.3 0.716
1dyj DDFDihydrofolate reductase 1.5.1.3 0.711
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.710
4fhb FOLDihydrofolate reductase 1.5.1.3 0.709
2w3m FOLDihydrofolate reductase 1.5.1.3 0.708
3ghw GHWDihydrofolate reductase 1.5.1.3 0.706
3ghv GHCDihydrofolate reductase 1.5.1.3 0.703
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.703
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.703
3dat MTXDihydrofolate reductase / 0.700
3tqb FOLDihydrofolate reductase / 0.699
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.697
4kfj FOLDihydrofolate reductase 1.5.1.3 0.695
1dhf FOLDihydrofolate reductase 1.5.1.3 0.686
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.685
2w3v TOPDihydrofolate reductase / 0.682
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.682
2w9h TOPDihydrofolate reductase 1.5.1.3 0.678
4x5i FOLDihydrofolate reductase 1.5.1.3 0.673
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.672
1dds MTXDihydrofolate reductase 1.5.1.3 0.665
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.665
2d0k FOLDihydrofolate reductase 1.5.1.3 0.664
1daj MOTDihydrofolate reductase 1.5.1.3 0.663
1ddr MTXDihydrofolate reductase 1.5.1.3 0.663
1ao8 MTXDihydrofolate reductase 1.5.1.3 0.661
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.654
1hfr MOTDihydrofolate reductase 1.5.1.3 0.653
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.652
2w3w VG9Dihydrofolate reductase / 0.651
3fyv XCFDihydrofolate reductase 1.5.1.3 0.651