Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1drb MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1drb MTXDihydrofolate reductase 1.5.1.3 1.036
1dhi MTXDihydrofolate reductase 1.5.1.3 1.027
3drc MTXDihydrofolate reductase 1.5.1.3 0.946
1dra MTXDihydrofolate reductase 1.5.1.3 0.926
1dhj MTXDihydrofolate reductase 1.5.1.3 0.915
5hi6 MTXDihydrofolate reductase / 0.866
4dfr MTXDihydrofolate reductase 1.5.1.3 0.864
4qi9 MTXDihydrofolate reductase / 0.862
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.857
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.854
4p66 MTXDihydrofolate reductase / 0.847
3och 2MXDihydrofolate reductase 1.5.1.3 0.839
1df7 MTXDihydrofolate reductase 1.5.1.3 0.828
2drc MTXDihydrofolate reductase 1.5.1.3 0.823
1u70 MTXDihydrofolate reductase 1.5.1.3 0.819
1tdr MTXDihydrofolate reductase 1.5.1.3 0.816
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.803
3eig MTXDihydrofolate reductase 1.5.1.3 0.794
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.784
3dau MTXDihydrofolate reductase 1.5.1.3 0.781
1dls MTXDihydrofolate reductase 1.5.1.3 0.775
4x5f FOLDihydrofolate reductase 1.5.1.3 0.772
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.766
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.758
3tq9 MTXDihydrofolate reductase / 0.756
3dat MTXDihydrofolate reductase / 0.754
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.753
1dyi FOLDihydrofolate reductase 1.5.1.3 0.751
4kjj FOLDihydrofolate reductase 1.5.1.3 0.751
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.750
5ccc DDFDihydrofolate reductase 1.5.1.3 0.747
1u72 MTXDihydrofolate reductase 1.5.1.3 0.746
3dfr MTXDihydrofolate reductase 1.5.1.3 0.746
2qk8 MTXDihydrofolate reductase / 0.744
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.744
1dyj DDFDihydrofolate reductase 1.5.1.3 0.741
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.739
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.737
1dre MTXDihydrofolate reductase 1.5.1.3 0.735
1ddr MTXDihydrofolate reductase 1.5.1.3 0.734
1drf FOLDihydrofolate reductase 1.5.1.3 0.734
1jol FFODihydrofolate reductase 1.5.1.3 0.732
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.731
4keb FOLDihydrofolate reductase 1.5.1.3 0.730
1jom FFODihydrofolate reductase 1.5.1.3 0.729
4kfj FOLDihydrofolate reductase 1.5.1.3 0.729
2w3m FOLDihydrofolate reductase 1.5.1.3 0.727
4m6k FOLDihydrofolate reductase 1.5.1.3 0.727
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.726
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.724
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.722
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.720
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.719
7dfr FOLDihydrofolate reductase 1.5.1.3 0.718
4i13 FOLDihydrofolate reductase 1.5.1.3 0.715
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.714
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.710
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.710
4p68 MTXDihydrofolate reductase / 0.709
1e26 GPBDihydrofolate reductase 1.5.1.3 0.706
1hfr MOTDihydrofolate reductase 1.5.1.3 0.706
3frd DHFDihydrofolate reductase 1.5.1.3 0.706
4x5h FOLDihydrofolate reductase 1.5.1.3 0.706
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.703
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.703
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.701
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.701
1dhf FOLDihydrofolate reductase 1.5.1.3 0.700
1hfq MOTDihydrofolate reductase 1.5.1.3 0.700
1re7 FOLDihydrofolate reductase 1.5.1.3 0.699
2d0k FOLDihydrofolate reductase 1.5.1.3 0.697
1hfp MOTDihydrofolate reductase 1.5.1.3 0.694
4m6l 21VDihydrofolate reductase 1.5.1.3 0.694
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.689
4x5g FOLDihydrofolate reductase 1.5.1.3 0.689
3ia4 MTXDihydrofolate reductase / 0.685
1dyh DZFDihydrofolate reductase 1.5.1.3 0.681
1daj MOTDihydrofolate reductase 1.5.1.3 0.680
2dhf DZFDihydrofolate reductase 1.5.1.3 0.680
3ghv GHCDihydrofolate reductase 1.5.1.3 0.680
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.676
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.674
4i1n FOLDihydrofolate reductase 1.5.1.3 0.669
1ohj COPDihydrofolate reductase 1.5.1.3 0.668
4x5i FOLDihydrofolate reductase 1.5.1.3 0.667
1ao8 MTXDihydrofolate reductase 1.5.1.3 0.658
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.654
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.650