Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dr5 NAP Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1dr5 NAPDihydrofolate reductase 1.5.1.3 1.212
8dfr NDPDihydrofolate reductase 1.5.1.3 1.176
1dr2 TAPDihydrofolate reductase 1.5.1.3 1.167
1dr3 TAPDihydrofolate reductase 1.5.1.3 1.114
2w3b NDPDihydrofolate reductase 1.5.1.3 1.109
3nxx NDPDihydrofolate reductase 1.5.1.3 1.051
3d84 NDPDihydrofolate reductase 1.5.1.3 0.945
3kjr NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.911
4m6j NDPDihydrofolate reductase 1.5.1.3 0.904
3tqa NDPDihydrofolate reductase / 0.881
4kl9 NDPDihydrofolate reductase 1.5.1.3 0.862
1rx1 NAPDihydrofolate reductase 1.5.1.3 0.853
3clb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.834
1dg8 NDPDihydrofolate reductase 1.5.1.3 0.829
3kjs NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.829
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.819
2cig 1DGDihydrofolate reductase 1.5.1.3 0.815
1j3j NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.794
1m78 NDPDihydrofolate reductase 1.5.1.3 0.791
1ia1 NDPDihydrofolate reductase 1.5.1.3 0.783
1drh NAPDihydrofolate reductase 1.5.1.3 0.758
3qls NDPDihydrofolate reductase 1.5.1.3 0.745
5ecc NAPDehydrofolate reductase type I / 0.736
2xw7 NDPDihydrofolate reductase / 0.721
3inv NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.715
1juv NDPDihydrofolate reductase 1.5.1.3 0.709
1ra3 NAPDihydrofolate reductase 1.5.1.3 0.709
3qlr NDPDihydrofolate reductase 1.5.1.3 0.703
1rx6 NAPDihydrofolate reductase 1.5.1.3 0.682
4xt6 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.681
2d5n NDPRiboflavin biosynthesis protein RibD 1.1.1.193 0.674
1ai9 NDPDihydrofolate reductase 1.5.1.3 0.671
5a03 NDPGlucose-fructose oxidoreductase / 0.666
5a05 NDPGlucose-fructose oxidoreductase / 0.661