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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dr3 TAP Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1dr3 TAPDihydrofolate reductase 1.5.1.3 1.214
1dr2 TAPDihydrofolate reductase 1.5.1.3 1.181
1dr5 NAPDihydrofolate reductase 1.5.1.3 1.114
8dfr NDPDihydrofolate reductase 1.5.1.3 1.102
2w3b NDPDihydrofolate reductase 1.5.1.3 1.065
3nxx NDPDihydrofolate reductase 1.5.1.3 1.018
3d84 NDPDihydrofolate reductase 1.5.1.3 0.855
4m6j NDPDihydrofolate reductase 1.5.1.3 0.849
3kjr NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.844
1rx1 NAPDihydrofolate reductase 1.5.1.3 0.840
1dg8 NDPDihydrofolate reductase 1.5.1.3 0.827
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.824
3tqa NDPDihydrofolate reductase / 0.821
2cig 1DGDihydrofolate reductase 1.5.1.3 0.815
4kl9 NDPDihydrofolate reductase 1.5.1.3 0.790
3clb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.785
1ra3 NAPDihydrofolate reductase 1.5.1.3 0.768
3kjs NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.767
1m78 NDPDihydrofolate reductase 1.5.1.3 0.763
5ecc NAPDehydrofolate reductase type I / 0.751
2xw7 NDPDihydrofolate reductase / 0.746
1j3j NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.724
4xt5 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.715
1drh NAPDihydrofolate reductase 1.5.1.3 0.712
3qls NDPDihydrofolate reductase 1.5.1.3 0.696
2d5n NDPRiboflavin biosynthesis protein RibD 1.1.1.193 0.694
1ia1 NDPDihydrofolate reductase 1.5.1.3 0.691
1rx6 NAPDihydrofolate reductase 1.5.1.3 0.677
5a03 NDPGlucose-fructose oxidoreductase / 0.653
4xt6 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.651