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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dr2 TAP Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1dr2 TAPDihydrofolate reductase 1.5.1.3 1.248
1dr3 TAPDihydrofolate reductase 1.5.1.3 1.181
1dr5 NAPDihydrofolate reductase 1.5.1.3 1.167
8dfr NDPDihydrofolate reductase 1.5.1.3 1.140
2w3b NDPDihydrofolate reductase 1.5.1.3 1.061
3nxx NDPDihydrofolate reductase 1.5.1.3 1.005
3d84 NDPDihydrofolate reductase 1.5.1.3 0.895
3kjr NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.858
4kl9 NDPDihydrofolate reductase 1.5.1.3 0.853
2cig 1DGDihydrofolate reductase 1.5.1.3 0.805
4m6j NDPDihydrofolate reductase 1.5.1.3 0.804
3clb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.799
3tqa NDPDihydrofolate reductase / 0.795
1dg8 NDPDihydrofolate reductase 1.5.1.3 0.791
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.787
1rx1 NAPDihydrofolate reductase 1.5.1.3 0.769
1m78 NDPDihydrofolate reductase 1.5.1.3 0.766
3kjs NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.757
5ecc NAPDehydrofolate reductase type I / 0.754
1ia1 NDPDihydrofolate reductase 1.5.1.3 0.737
1j3j NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.736
1ra3 NAPDihydrofolate reductase 1.5.1.3 0.726
2xw7 NDPDihydrofolate reductase / 0.721
3inv NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.711
1drh NAPDihydrofolate reductase 1.5.1.3 0.710
2azn NAP2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase / 0.676
4xt5 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.671
1rx6 NAPDihydrofolate reductase 1.5.1.3 0.666
1rx8 NAPDihydrofolate reductase 1.5.1.3 0.656
1ai9 NDPDihydrofolate reductase 1.5.1.3 0.651
3qls NDPDihydrofolate reductase 1.5.1.3 0.651