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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1do8 NAD NAD-dependent malic enzyme, mitochondrial 1.1.1.38

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1do8 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 1.094
1efl NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 1.025
1pj3 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 1.024
1pj2 NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.975
1efk NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.950
1gq2 NAPNADP-dependent malic enzyme 1.1.1.40 0.907
1qr6 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.821
1gz4 ATPNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.758
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.728
1pj4 ATPNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.712
1llq NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.709
5a05 NDPGlucose-fructose oxidoreductase / 0.700
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.699
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.698
3tnl NADShikimate dehydrogenase (NADP(+)) / 0.693
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.690
3d64 NADAdenosylhomocysteinase / 0.689
3t4e NADQuinate/shikimate dehydrogenase / 0.685
5a03 NDPGlucose-fructose oxidoreductase / 0.681
3toz NADShikimate dehydrogenase (NADP(+)) / 0.680
4jbi NDPAlcohol dehydrogenase (Zinc) / 0.678
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.666
2vq3 NAPMetalloreductase STEAP3 / 0.666
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.665
5a02 NAPGlucose-fructose oxidoreductase / 0.664
4c4o NADSADH / 0.663
1yqd NAPSinapyl alcohol dehydrogenase / 0.662
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.662
4z0p NDPNAD-dependent dehydrogenase / 0.659
4weq NAPNAD-dependent dehydrogenase / 0.655
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 0.654
2rcy NAPPyrroline-5-carboxylate reductase / 0.653
1ky4 NADAdenosylhomocysteinase 3.3.1.1 0.652