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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dhi MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1dhi MTXDihydrofolate reductase 1.5.1.3 1.052
1drb MTXDihydrofolate reductase 1.5.1.3 1.027
3drc MTXDihydrofolate reductase 1.5.1.3 0.981
1dra MTXDihydrofolate reductase 1.5.1.3 0.925
4dfr MTXDihydrofolate reductase 1.5.1.3 0.888
2drc MTXDihydrofolate reductase 1.5.1.3 0.885
3och 2MXDihydrofolate reductase 1.5.1.3 0.884
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.880
4qi9 MTXDihydrofolate reductase / 0.880
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.863
4p66 MTXDihydrofolate reductase / 0.846
1df7 MTXDihydrofolate reductase 1.5.1.3 0.841
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.834
1u70 MTXDihydrofolate reductase 1.5.1.3 0.832
5hi6 MTXDihydrofolate reductase / 0.828
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.807
1tdr MTXDihydrofolate reductase 1.5.1.3 0.805
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.803
3dau MTXDihydrofolate reductase 1.5.1.3 0.791
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.781
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.775
4x5f FOLDihydrofolate reductase 1.5.1.3 0.775
1dls MTXDihydrofolate reductase 1.5.1.3 0.774
1u72 MTXDihydrofolate reductase 1.5.1.3 0.774
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.770
1dhj MTXDihydrofolate reductase 1.5.1.3 0.767
2qk8 MTXDihydrofolate reductase / 0.766
5ccc DDFDihydrofolate reductase 1.5.1.3 0.758
4x5g FOLDihydrofolate reductase 1.5.1.3 0.750
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.749
4keb FOLDihydrofolate reductase 1.5.1.3 0.747
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.745
2w3m FOLDihydrofolate reductase 1.5.1.3 0.744
1jol FFODihydrofolate reductase 1.5.1.3 0.742
3dfr MTXDihydrofolate reductase 1.5.1.3 0.740
1dre MTXDihydrofolate reductase 1.5.1.3 0.739
1dyj DDFDihydrofolate reductase 1.5.1.3 0.739
4i13 FOLDihydrofolate reductase 1.5.1.3 0.738
1dyh DZFDihydrofolate reductase 1.5.1.3 0.737
1hfr MOTDihydrofolate reductase 1.5.1.3 0.737
3eig MTXDihydrofolate reductase 1.5.1.3 0.736
3ia4 MTXDihydrofolate reductase / 0.736
1jom FFODihydrofolate reductase 1.5.1.3 0.732
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.731
4m6k FOLDihydrofolate reductase 1.5.1.3 0.730
4kfj FOLDihydrofolate reductase 1.5.1.3 0.729
4x5i FOLDihydrofolate reductase 1.5.1.3 0.729
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.729
7dfr FOLDihydrofolate reductase 1.5.1.3 0.729
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.725
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.725
1hfp MOTDihydrofolate reductase 1.5.1.3 0.716
4kjj FOLDihydrofolate reductase 1.5.1.3 0.712
4p68 MTXDihydrofolate reductase / 0.711
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.710
3tq9 MTXDihydrofolate reductase / 0.709
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.708
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.705
1dyi FOLDihydrofolate reductase 1.5.1.3 0.704
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.704
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.699
4x5h FOLDihydrofolate reductase 1.5.1.3 0.698
1hfq MOTDihydrofolate reductase 1.5.1.3 0.697
2d0k FOLDihydrofolate reductase 1.5.1.3 0.697
1dhf FOLDihydrofolate reductase 1.5.1.3 0.696
1e26 GPBDihydrofolate reductase 1.5.1.3 0.692
4m6l 21VDihydrofolate reductase 1.5.1.3 0.692
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.690
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.690
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.688
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.688
3dat MTXDihydrofolate reductase / 0.684
4i1n FOLDihydrofolate reductase 1.5.1.3 0.682
3ghw GHWDihydrofolate reductase 1.5.1.3 0.680
1dds MTXDihydrofolate reductase 1.5.1.3 0.679
2zza FOLDihydrofolate reductase / 0.678
1ohj COPDihydrofolate reductase 1.5.1.3 0.674
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.672
1re7 FOLDihydrofolate reductase 1.5.1.3 0.671
4fpy 0V8Sialidase B 3.2.1.18 0.669
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.666
1ddr MTXDihydrofolate reductase 1.5.1.3 0.664
1daj MOTDihydrofolate reductase 1.5.1.3 0.663
1drf FOLDihydrofolate reductase 1.5.1.3 0.661
2vcm M11Isopenicillin N synthase 1.21.3.1 0.661
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.659
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.656
2dhf DZFDihydrofolate reductase 1.5.1.3 0.654
1eqh FLPProstaglandin G/H synthase 1 1.14.99.1 0.650