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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1daw ANP Casein kinase II subunit alpha 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1daw ANPCasein kinase II subunit alpha 2.7.11.1 1.137
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 1.024
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.986
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.876
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.855
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.854
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.805
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.789
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.788
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.785
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.784
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.783
2pui ADPMethylthioribose kinase 2.7.1.100 0.781
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.778
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.778
1cm8 ANPMitogen-activated protein kinase 12 / 0.777
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.777
2olc ADPMethylthioribose kinase 2.7.1.100 0.775
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.774
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.772
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.771
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.770
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.768
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.766
1m0w ANPGlutathione synthetase 6.3.2.3 0.763
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.763
5iqb GNPBifunctional AAC/APH 2.3.1 0.763
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.761
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.761
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.761
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.760
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.756
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.755
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.748
5dn3 ATPAurora kinase A 2.7.11.1 0.747
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.745
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.745
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.742
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.742
3c4z ADPRhodopsin kinase / 0.742
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.739
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.739
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.738
4ffl ADPUncharacterized protein / 0.737
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.737
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.736
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.736
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.734
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.733
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.733
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.732
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.732
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.732
2pun ACPMethylthioribose kinase 2.7.1.100 0.731
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.731
5dt3 ATPAurora kinase A 2.7.11.1 0.731
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.730
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.730
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.729
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.729
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.729
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.728
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.728
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.728
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.727
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.727
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.727
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.726
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.726
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.724
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.724
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.723
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.722
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.721
1mq4 ADPAurora kinase A 2.7.11.1 0.720
4xlv ACPInsulin receptor 2.7.10.1 0.720
1ol5 ADPAurora kinase A 2.7.11.1 0.719
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.719
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.719
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.719
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.718
4q5h ANPProtein kinase OspG 2.7 0.718
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.717
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.717
4ffr ATPUncharacterized protein / 0.716
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.715
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.714
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.714
1ol6 ATPAurora kinase A 2.7.11.1 0.712
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.710
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.710
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.710
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.709
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.709
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.708
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.708
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.707
4bn1 ADPAurora kinase A 2.7.11.1 0.707
5iqh GNPBifunctional AAC/APH 2.3.1 0.707
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.705
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.705
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.703
4dee ADPAurora kinase A 2.7.11.1 0.702
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.701
4ysj ADPCalmodulin-like domain protein kinase / 0.701
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.700
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.700
5iqa GNPBifunctional AAC/APH 2.3.1 0.700
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.699
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.699
5dr2 ATPAurora kinase A 2.7.11.1 0.699
5iqd GNPBifunctional AAC/APH 2.3.1 0.699
5iqe GNPBifunctional AAC/APH 2.3.1 0.698
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.697
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.695
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.695
5byl GCPBifunctional AAC/APH 2.3.1 0.695
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.694
3c50 ADPRhodopsin kinase / 0.694
2pml ANPUncharacterized protein / 0.691
2pul ACPMethylthioribose kinase 2.7.1.100 0.691
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.691
3cly ACPFibroblast growth factor receptor 2 / 0.691
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.691
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.691
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.690
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.690
4ork GDPBifunctional AAC/APH 2.3.1 0.690
4utd ACPAurora kinase A 2.7.11.1 0.690
3rv4 ADPBiotin carboxylase 6.3.4.14 0.689
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.689
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.688
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.688
4qny ANPMitogen activated protein kinase, putative / 0.688
5iqi GNPBifunctional AAC/APH 2.3.1 0.688
4ceg ADPAurora kinase A 2.7.11.1 0.687
5drd ATPAurora kinase A 2.7.11.1 0.687
1u54 ACPActivated CDC42 kinase 1 / 0.686
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.686
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.685
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.685
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.685
5eg3 ACPFibroblast growth factor receptor 2 / 0.685
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.684
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.684
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.684
5dnr ATPAurora kinase A 2.7.11.1 0.684
2hgs ADPGlutathione synthetase 6.3.2.3 0.683
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.683
3bu5 ATPInsulin receptor 2.7.10.1 0.683
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.682
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.682
4gyi ADPUncharacterized protein / 0.682
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.682
2vqd AP2Biotin carboxylase 6.3.4.14 0.681
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.681
3wnz ADPAlanine--anticapsin ligase / 0.680
4o4f ATPKinase / 0.680
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.679
5csh ATPCasein kinase II subunit alpha 2.7.11.1 0.679
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.678
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.678
3q5i ANPProtein kinase, putative / 0.678
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.677
3oro AGSSerine/threonine protein kinase / 0.677
5ckw ANPUncharacterized protein / 0.677
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.676
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.676
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.676
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.676
2pup ADPMethylthioribose kinase 2.7.1.100 0.675
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.675
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.675
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.675
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.673
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.672
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.672
2dwb ANPAurora kinase A 2.7.11.1 0.672
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.672
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.672
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.671
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
4fu0 ADPD-alanine--D-alanine ligase / 0.671
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.671
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.670
5ce3 ADPProtein kinase YopO / 0.669
1ol7 ADPAurora kinase A 2.7.11.1 0.668
3tw6 ADPPyruvate carboxylase / 0.668
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
4o1p ANPRibonuclease L / 0.667
4o4e ATPKinase / 0.667
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.666
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.665
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.664
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.664
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.664
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.664
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.664
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.663
5iqf GDPBifunctional AAC/APH 2.3.1 0.663
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.662
3t8o ATPRhodopsin kinase / 0.662
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.662
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.662
3llt ANPProtein serine/threonine kinase-1 / 0.661
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.658
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4ix5 ANPUncharacterized protein / 0.658
4zol ACPTubulin tyrosine ligase / 0.658
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.657
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.657
5dos ATPAurora kinase A 2.7.11.1 0.657
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.656
5iqg GDPBifunctional AAC/APH 2.3.1 0.656
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.655
2pyw ADPMethylthioribose kinase 2.7.1.100 0.655
5dt4 ATPAurora kinase A 2.7.11.1 0.655
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.654
3t54 ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.654
4f0f ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.654
4dt8 ADNAPH(2'')-Id / 0.653
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.652
3orm AGSSerine/threonine protein kinase / 0.652
2qoc ANPEphrin type-A receptor 3 2.7.10.1 0.651
3ibq ATPPyridoxal kinase / 0.651
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.651
2py3 ACPFibroblast growth factor receptor 2 / 0.650
3g8d ADPBiotin carboxylase 6.3.4.14 0.650
4ffm ADPUncharacterized protein / 0.650