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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1daj MOT Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1daj MOTDihydrofolate reductase 1.5.1.3 1.143
1e26 GPBDihydrofolate reductase 1.5.1.3 0.714
1dhj MTXDihydrofolate reductase 1.5.1.3 0.709
4p66 MTXDihydrofolate reductase / 0.694
2drc MTXDihydrofolate reductase 1.5.1.3 0.686
3tq9 MTXDihydrofolate reductase / 0.686
1drb MTXDihydrofolate reductase 1.5.1.3 0.680
3och 2MXDihydrofolate reductase 1.5.1.3 0.677
1hfp MOTDihydrofolate reductase 1.5.1.3 0.673
1hfq MOTDihydrofolate reductase 1.5.1.3 0.672
3drc MTXDihydrofolate reductase 1.5.1.3 0.672
4dfr MTXDihydrofolate reductase 1.5.1.3 0.672
3dau MTXDihydrofolate reductase 1.5.1.3 0.671
1dra MTXDihydrofolate reductase 1.5.1.3 0.670
4p68 MTXDihydrofolate reductase / 0.669
1u70 MTXDihydrofolate reductase 1.5.1.3 0.668
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.668
3eig MTXDihydrofolate reductase 1.5.1.3 0.667
7dfr FOLDihydrofolate reductase 1.5.1.3 0.665
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.664
5hi6 MTXDihydrofolate reductase / 0.664
1dhi MTXDihydrofolate reductase 1.5.1.3 0.663
1dre MTXDihydrofolate reductase 1.5.1.3 0.663
1dyj DDFDihydrofolate reductase 1.5.1.3 0.658
1df7 MTXDihydrofolate reductase 1.5.1.3 0.657
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.657
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.653
2dhf DZFDihydrofolate reductase 1.5.1.3 0.653
4x5g FOLDihydrofolate reductase 1.5.1.3 0.652