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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1d3g BRE Dihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1d3g BREDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 1.231
2prh 238Dihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.819
1uuo BRFDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.817
2b0m 201Dihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.738
1toi HCIAspartate aminotransferase 2.6.1.1 0.677
1toj HCIAspartate aminotransferase 2.6.1.1 0.677
4kdr SAHUbiquinone biosynthesis O-methyltransferase / 0.672
3sxj SAMPutative methyltransferase / 0.670
1khz ADVADP-ribose pyrophosphatase 3.6.1.13 0.665
4i13 FOLDihydrofolate reductase 1.5.1.3 0.664
1x09 IPEDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) 2.5.1.31 0.660
1u4s BIHL-lactate dehydrogenase 1.1.1.27 0.655
3lnc 5GPGuanylate kinase / 0.655
1x28 PGUAspartate aminotransferase 2.6.1.1 0.652
3aej AA5Methionine gamma-lyase / 0.652