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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1cqx FAD Flavohemoprotein

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1cqx FADFlavohemoprotein / 1.364
1krh FADBenzoate 1,2-dioxygenase electron transfer component 1.18.1.3 1.058
3fpk FADFerredoxin-NADP reductase / 1.044
4wqm FADToluene-4-monooxygenase electron transfer component 1.18.1.3 1.030
3w5h FADNADH-cytochrome b5 reductase 3 1.6.2.2 1.023
3w2f FADNADH-cytochrome b5 reductase 3 1.6.2.2 1.011
4uaj FADNa(+)-translocating NADH-quinone reductase subunit F / 1.005
1umk FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.980
3w2e FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.978
3qe2 FADNADPH--cytochrome P450 reductase / 0.968
3ojw FADNADPH--cytochrome P450 reductase / 0.952
1ja1 FADNADPH--cytochrome P450 reductase / 0.950
3qfc FADNADPH--cytochrome P450 reductase / 0.949
3qfs FADNADPH--cytochrome P450 reductase / 0.944
1bx1 FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.943
2eix FADNADH-cytochrome b5 reductase / 0.940
1fdr FADFerredoxin--NADP reductase 1.18.1.2 0.938
1qg0 FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.935
1f20 FADNitric oxide synthase, brain 1.14.13.39 0.934
1fnd FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.933
1gaw FADFerredoxin / 0.916
2qdx FADFerredoxin--NADP+ reductase / 0.911
1qh0 FADFerredoxin--NADP reductase 1.18.1.2 0.907
2vnk FADNADPH:ferredoxin reductase / 0.907
2r6h FADNa(+)-translocating NADH-quinone reductase subunit F / 0.904
4b4d FADFerredoxin-NADP reductase / 0.903
3mhp FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.901
1que FADFerredoxin--NADP reductase 1.18.1.2 0.900
1amo FADNADPH--cytochrome P450 reductase / 0.898
1fnb FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.898
1tll FADNitric oxide synthase, brain 1.14.13.39 0.895
2rc6 FADFerredoxin--NADP reductase / 0.895
1gvh FADFlavohemoprotein / 0.894
1qgy FADFerredoxin--NADP reductase 1.18.1.2 0.894
4fk8 FADFerredoxin--NADP reductase / 0.893
3crz FADFerredoxin--NADP+ reductase / 0.891
1gjr FADFerredoxin--NADP reductase 1.18.1.2 0.887
3ojx FADNADPH--cytochrome P450 reductase / 0.887
4yaf FADNADPH--cytochrome P450 reductase / 0.887
2ok8 FADFerredoxin--NADP reductase, apicoplast / 0.885
1w34 FADFerredoxin--NADP reductase 1.18.1.2 0.884
1w35 FADFerredoxin--NADP reductase 1.18.1.2 0.883
2rc5 FADFerredoxin--NADP reductase / 0.883
3qfr FADNADPH--cytochrome P450 reductase / 0.881
1e64 FADFerredoxin--NADP reductase 1.18.1.2 0.880
1gr1 FADFerredoxin--NADP reductase 1.18.1.2 0.880
4y7c FADNADPH--cytochrome P450 reductase / 0.879
2bn4 FADNADPH--cytochrome P450 reductase / 0.877
3zbt FADFerredoxin--NADP reductase 1.18.1.2 0.877
1go2 FADFerredoxin--NADP reductase 1.18.1.2 0.873
1sm4 FADFerredoxin--NADP reductase / 0.873
2vyq FADFerredoxin--NADP reductase 1.18.1.2 0.872
1qgz FADFerredoxin--NADP reductase 1.18.1.2 0.869
1e62 FADFerredoxin--NADP reductase 1.18.1.2 0.868
1e63 FADFerredoxin--NADP reductase 1.18.1.2 0.867
1ogi FADFerredoxin--NADP reductase 1.18.1.2 0.867
1h85 FADFerredoxin--NADP reductase 1.18.1.2 0.865
2bpo FADNADPH--cytochrome P450 reductase / 0.861
1gaq FADFerredoxin / 0.855
2bf4 FADNADPH--cytochrome P450 reductase / 0.854
3jqr FADFerredoxin--NADP reductase, apicoplast / 0.854
4c43 FADFerredoxin--NADP reductase 1.18.1.2 0.854
2ok7 FADFerredoxin--NADP reductase, apicoplast / 0.851
1b2r FADFerredoxin--NADP reductase 1.18.1.2 0.850
2pia FMNPhthalate dioxygenase reductase / 0.849
2vnj FADNADPH:ferredoxin reductase / 0.847
2vnh FADNADPH:ferredoxin reductase / 0.841
2bgi FADNADPH:ferredoxin reductase / 0.834
1ib0 FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.833
1bjk FADFerredoxin--NADP reductase 1.18.1.2 0.829
1ogj FADFerredoxin--NADP reductase 1.18.1.2 0.827
1j9z FADNADPH--cytochrome P450 reductase / 0.825
2bgj FADNADPH:ferredoxin reductase / 0.824
4k1x FADNADPH:ferredoxin reductase / 0.824
1ewy FADFerredoxin--NADP reductase 1.18.1.2 0.823
1h42 FADFerredoxin--NADP reductase 1.18.1.2 0.823
2xnc FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.822
2cnd FADNitrate reductase [NADH] 1.7.1.1 0.815
2b5o FADFerredoxin--NADP reductase 1.18.1.2 0.810
4af7 FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.807
4y9u FADNADPH--cytochrome P450 reductase / 0.805
3vo2 FADFerredoxin--NADP reductase / 0.796
1bx0 FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.795
4y9r FADNADPH--cytochrome P450 reductase / 0.776
4yao FADNADPH--cytochrome P450 reductase / 0.770
1ep3 FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit / 0.767
1ndh FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.767
4bpr FADFerredoxin--NADP reductase 1.18.1.2 0.759
3zc3 FADFerredoxin--NADP reductase 1.18.1.2 0.757
4yau FADNADPH--cytochrome P450 reductase / 0.757
5cho FADFlavin reductase / 0.756
1w87 FADFerredoxin--NADP reductase 1.18.1.2 0.751
1fnc FDAFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.749
1i7p FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.746
4f07 FADStyrene monooxygenase component 2 / 0.738
1ja0 FADNADPH--cytochrome P450 reductase / 0.727
3qft FADNADPH--cytochrome P450 reductase / 0.727
2iml FMNUncharacterized protein / 0.724
2gpj FADSiderophore-interacting protein / 0.716
1i0s FMNFerric-chelate reductase (NAD(P)H) / 0.715
4eer FMNPhototropin-2 2.7.11.1 0.709
3w5u FADFerredoxin / 0.708
4hj4 FMNLOV protein / 0.704
3bnk FMNFlavoredoxin / 0.703
4hms FMNPhenazine biosynthesis protein PhzG 1.4 0.702
4hhd FMNPhototropin-1 2.7.11.1 0.701
3t50 FMNBlue-light-activated histidine kinase 2.7.13.3 0.698
1a8p FADFerredoxin--NADP reductase / 0.697
1pkv RBFRiboflavin synthase 2.5.1.9 0.697
1tj1 FADBifunctional protein PutA 1.5.5.2 0.697
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.697
4af6 FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.697
1usc FMNMonooxygenase / 0.695
2hq9 FADMll6688 protein / 0.695
3pl8 FADPyranose 2-oxidase / 0.694
1tdo FADL-amino-acid oxidase 1.4.3.2 0.691
2i02 FMNPyridoxamine 5'-phosphate oxidase-related, FMN-binding / 0.691
2i51 FMNPyridoxamine 5'-phosphate oxidase-related, FMN-binding / 0.690
2igo FADPyranose 2-oxidase / 0.690
1cnf FADNitrate reductase [NADH] 1.7.1.1 0.688
1flm FMNFMN-binding protein / 0.686
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.686
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.685
2gjn FMNNitronate monooxygenase 1.13.12.16 0.684
3axb FADPutative oxidoreductase / 0.683
4nmd FDABifunctional protein PutA / 0.683
1eje FMNProtein MTH_152 / 0.680
1rz0 FADPhenol 2-hydroxylase component B / 0.680
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.680
3lsh FADPyranose 2-oxidase / 0.679
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.678
3a6q FMNFMN-binding protein / 0.678
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.677
2ign FADPyranose 2-oxidase / 0.676
4rhe FMNFlavin prenyltransferase UbiX / 0.676
1xpq FADPolyamine oxidase FMS1 / 0.675
3lsi FADPyranose 2-oxidase / 0.674
4hmx FMNPyridoxamine 5'-phosphate oxidase / 0.673
5ebu FMNLactate oxidase / 0.673
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.672
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.672
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.671
3ept FDAPutative FAD-monooxygenase / 0.671
4icy FADPgaE / 0.671
4j57 FADThioredoxin reductase 2 1.8.1.9 0.671
5i39 FADL-amino acid deaminase / 0.669
2dvl FADAcyl-CoA dehydrogenase / 0.668
4hj3 FMNLOV protein / 0.668
4mok FADPyranose 2-oxidase / 0.668
2fzn FADBifunctional protein PutA 1.5.5.2 0.667
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.667
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.667
5l3d FADLysine-specific histone demethylase 1A 1 0.666
4ylf FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog / 0.665
1reo FADL-amino-acid oxidase 1.4.3.2 0.664
3a20 FMNFMN-binding protein / 0.664
3u5s FADFAD-linked sulfhydryl oxidase ALR 1.8.3.2 0.664
4o8a FADBifunctional protein PutA 1.2.1.88 0.664
4ybn FADFlavin-nucleotide-binding protein / 0.664
1owo FADDeoxyribodipyrimidine photo-lyase 4.1.99.3 0.663
2cdu FADNADH oxidase / 0.663
2e1m FADL-glutamate oxidase / 0.663
1tdk FADL-amino-acid oxidase 1.4.3.2 0.662
1tdn FADL-amino-acid oxidase 1.4.3.2 0.662
3vy2 FMNFMN-binding protein / 0.662
5buk FADFADH2-dependent halogenase / 0.662
2ard FDAFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.661
3a6r FMNFMN-binding protein / 0.661
3u2m FADFAD-linked sulfhydryl oxidase ALR 1.8.3.2 0.661
3k4c FADPyranose 2-oxidase / 0.660
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.660
1owp FADDeoxyribodipyrimidine photo-lyase 4.1.99.3 0.659
5efw FMNNPH1-1 / 0.659
1joa FADNADH peroxidase 1.11.1.1 0.658
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.658
2qa1 FADPgaE / 0.657
3ae4 FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.657
3kpk FADSulfide-quinone reductase / 0.657
3urh FADDihydrolipoyl dehydrogenase / 0.657
4dna FADProbable glutathione reductase / 0.657
2ou5 FMNPyridoxamine 5'-phosphate oxidase-related FMN-binding protein / 0.656
4r3a RBFBlue-light-activated histidine kinase 2 2.7.13.3 0.656
1owm FADDeoxyribodipyrimidine photo-lyase 4.1.99.3 0.655
3ad9 FADSubunit beta of sarcosine oxidase / 0.655
5ahk FADAcetolactate synthase II, large subunit / 0.655
4u2s FDACholesterol oxidase 1.1.3.6 0.654
1jr8 FADFAD-linked sulfhydryl oxidase ERV2 1.8.3.2 0.653
1sbz FMNProbable UbiX-like flavin prenyltransferase / 0.653
2e83 FMNFMN-binding protein / 0.653
2ed4 FAD4-hydroxyphenylacetate 3-monooxygenase reductase component 1.5.1.36 0.652
3vy5 FMNFMN-binding protein / 0.651
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.650
3cgc FADCoenzyme A disulfide reductase / 0.650
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.650
3tk0 FADFAD-linked sulfhydryl oxidase ALR 1.8.3.2 0.650