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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1cq8 PY6 Aspartate aminotransferase 2.6.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1cq8 PY6Aspartate aminotransferase 2.6.1.1 1.294
1cq7 PY5Aspartate aminotransferase 2.6.1.1 1.258
1arg PPDAspartate aminotransferase 2.6.1.1 1.122
1ahg TYR_PLPAspartate aminotransferase 2.6.1.1 1.018
1akb PPDAspartate aminotransferase, mitochondrial 2.6.1.1 0.969
1arh PPDAspartate aminotransferase 2.6.1.1 0.940
1akc PPEAspartate aminotransferase, mitochondrial 2.6.1.1 0.919
1maq PGUAspartate aminotransferase, mitochondrial 2.6.1.1 0.907
1x28 PGUAspartate aminotransferase 2.6.1.1 0.906
1cq6 PY4Aspartate aminotransferase 2.6.1.1 0.891
3qpg 3QPAspartate aminotransferase 2.6.1.1 0.840
4dbc 3QPAspartate aminotransferase 2.6.1.1 0.840
1ivr CBAAspartate aminotransferase, mitochondrial 2.6.1.1 0.834
4w5k PLPAspartate aminotransferase, mitochondrial / 0.812
1map KETAspartate aminotransferase, mitochondrial 2.6.1.1 0.805
3ele PLPAminotransferase / 0.777
4gdy 0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.775
4itx IN5Cystathionine beta-lyase MetC 4.4.1.8 0.764
4ge4 0KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.762
3ei8 PL5LL-diaminopimelate aminotransferase, chloroplastic / 0.753
4emy PLPAminotransferase class I and II / 0.716
1cl2 PPGCystathionine beta-lyase MetC 4.4.1.8 0.699
1asc NPLAspartate aminotransferase 2.6.1.1 0.691
1oxo IK2Aspartate aminotransferase, mitochondrial 2.6.1.1 0.689
1aka PLPAspartate aminotransferase, mitochondrial 2.6.1.1 0.682
4rkd KETAminotransferase / 0.681
4wxg 2BOSerine hydroxymethyltransferase / 0.678
4eb7 PLPCysteine desulfurase IscS 2 / 0.675
4je5 PLPAromatic/aminoadipate aminotransferase 1 2.6.1.39 0.669
1dfo PLGSerine hydroxymethyltransferase 2.1.2.1 0.662
2fq6 P3FCystathionine beta-lyase MetC 4.4.1.8 0.662
4wxf PLGSerine hydroxymethyltransferase / 0.661
4ge7 0K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.660
4geb 0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.659
1ndc TYDNucleoside diphosphate kinase, cytosolic 2.7.4.6 0.650