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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1cjw COT Serotonin N-acetyltransferase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1cjw COTSerotonin N-acetyltransferase / 1.558
1kuv CA5Serotonin N-acetyltransferase / 1.278
1l0c COTSerotonin N-acetyltransferase / 1.232
1kuy COTSerotonin N-acetyltransferase / 1.231
1ib1 COTSerotonin N-acetyltransferase / 1.102
1kux CA3Serotonin N-acetyltransferase / 1.055
2bsw CAOProbable acetyltransferase / 0.898
2jdc CAOProbable acetyltransferase / 0.882
2jdd ACOProbable acetyltransferase / 0.882
2q4v ACODiamine acetyltransferase 2 2.3.1.57 0.848
1i12 ACOGlucosamine 6-phosphate N-acetyltransferase / 0.847
2bei ACODiamine acetyltransferase 2 2.3.1.57 0.836
2fxf ACODiamine acetyltransferase 1 / 0.816
5kf1 ACOPredicted acetyltransferase / 0.808
5kgh ACOPredicted acetyltransferase / 0.803
2b3v ACODiamine acetyltransferase 1 / 0.795
5kgj ACOPredicted acetyltransferase / 0.793
5kf8 ACOPredicted acetyltransferase / 0.791
3s6f COAUncharacterized protein / 0.790
2c27 ACOMycothiol acetyltransferase 2.3.1.189 0.788
5kf9 ACOPredicted acetyltransferase / 0.788
1bob ACOHistone acetyltransferase type B catalytic subunit / 0.784
1qsm ACOHistone acetyltransferase HPA2 / 0.783
4jwp ACOGCN5-related N-acetyltransferase / 0.779
5kf2 ACOPredicted acetyltransferase / 0.777
1pu9 COAHAT A1 / 0.775
4lx9 ACON-alpha-acetyltransferase 2.3.1 0.775
2cnt COARibosomal-protein-alanine acetyltransferase / 0.773
1cm0 COAHistone acetyltransferase KAT2B 2.3.1.48 0.772
3sxn COAN-acetyltransferase Eis / 0.767
1s5k COAAminoglycoside N(6')-acetyltransferase type 1 / 0.761
1p0h COAMycothiol acetyltransferase 2.3.1.189 0.760
2x7b COAN-alpha-acetyltransferase 2.3.1 0.756
2a4n COAAac(6')-Ii protein / 0.754
2bue COAAAC(6')-Ib / 0.754
4ucn MYAGlycylpeptide N-tetradecanoyltransferase / 0.752
5ag7 MYAGlycylpeptide N-tetradecanoyltransferase / 0.748
1p0h ACOMycothiol acetyltransferase 2.3.1.189 0.746
3dr8 ACOL-methionine sulfoximine/L-methionine sulfone acetyltransferase / 0.746
3r96 ACOMccE protein / 0.742
3f8k COAUncharacterized protein / 0.741
4kvx ACON-terminal acetyltransferase A complex catalytic subunit ard1 2.3.1.88 0.741
2rc4 ACOHistone acetyltransferase KAT6A / 0.740
4u9v ACON-alpha-acetyltransferase 40 2.3.1 0.738
2ozg COAGCN5-related N-acetyltransferase / 0.731
2vqy ACOAAC(6')-Ib / 0.731
3r95 ACOMccE protein / 0.730
1s3z COAAminoglycoside N(6')-acetyltransferase type 1 / 0.729
4r3k COAN-alpha-acetyltransferase 2.3.1 0.728
1m4d COAAminoglycoside 2'-N-acetyltransferase 2.3.1 0.727
4kvm SER_ALA_SER_GLU_1XEN-terminal acetyltransferase A complex catalytic subunit ard1 2.3.1.88 0.725
1s7n COAAcetyl transferase / 0.722
1qsn COAHAT A1 / 0.721
1ozp ACOMycothiol acetyltransferase 2.3.1.189 0.720
2vez ACOGlucosamine 6-phosphate acetyltransferase, putative / 0.719
2wsa MYAGlycylpeptide N-tetradecanoyltransferase / 0.719
3r1k COAN-acetyltransferase Eis / 0.719
3to6 LYS_CMCHistone acetyltransferase ESA1 / 0.719
3vwe COAAlpha-tubulin N-acetyltransferase 1 / 0.719
2cy2 ACOProbable acetyltransferase / 0.718
2r8v ACOAmino-acid acetyltransferase / 0.718
4zm6 ACON-acetyl-beta-D glucosaminidase / 0.718
5kf8 COAPredicted acetyltransferase / 0.718
4qvt ACOAcetyltransferase YpeA 2.3.1 0.717
5kgp ACOPredicted acetyltransferase / 0.717
2ync YNCGlycylpeptide N-tetradecanoyltransferase / 0.715
3bj7 COADiamine acetyltransferase 1 / 0.713
4bhw 01KHistone acetyltransferase p300 / 0.713
2y0m ACOHistone acetyltransferase KAT8 / 0.712
3te4 ACODopamine N-acetyltransferase / 0.711
4a32 MYAGlycylpeptide N-tetradecanoyltransferase / 0.710
5c88 COAN-alpha-acetyltransferase / 0.710
1m1d LYXHAT A1 / 0.709
5kf2 COAPredicted acetyltransferase / 0.709
1n71 COAAac(6')-Ii protein / 0.705
3exn ACOProbable acetyltransferase / 0.705
2qir COAAminoglycoside 6-N-acetyltransferase type Ib11 / 0.703
1mjb ACOHistone acetyltransferase ESA1 / 0.702
1qsr ACOHAT A1 / 0.697
1b87 ACOAac(6')-Ii protein / 0.696
1m4i COAAminoglycoside 2'-N-acetyltransferase 2.3.1 0.696
2vzz SCAPutative succinyl-CoA transferase Rv0802c 2.8.3 0.691
1j4j ACOAcetyltransferase 2.3.1 0.689
4ava ACOAcetyltransferase Pat 2.3.1 0.689
1ghe ACOAcetyltransferase 2.3.1 0.688
2psw COAN-alpha-acetyltransferase 50 / 0.686
1tiq COASpermidine/spermine N(1)-acetyltransferase / 0.683
3fbu COAAcetyltransferase, GNAT family / 0.683
2prb COAAminoglycoside 6-N-acetyltransferase type Ib11 / 0.679
1mja COAHistone acetyltransferase ESA1 / 0.676
1pua COAHAT A1 / 0.676
2ge3 ACOProbable acetyltransferase / 0.676
2vbq BSJAminoglycoside N(6')-acetyltransferase type 1 / 0.676
3zj0 ACOPutative acetyltransferase OgpAT / 0.674
2cns ACORibosomal-protein-alanine acetyltransferase / 0.664
2giv ACOHistone acetyltransferase KAT8 / 0.663
2o28 COAGlucosamine 6-phosphate N-acetyltransferase / 0.662
4r87 COASpermidine N(1)-acetyltransferase / 0.657
3ryo ACON-acetyltransferase Eis / 0.656
4hkf ACOAlpha-tubulin N-acetyltransferase 1 / 0.656
4ri1 ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase 2.3.1.202 0.654
3pgp ACOUncharacterized protein / 0.653
4kub COAUncharacterized protein / 0.653
3biy 01KHistone acetyltransferase p300 / 0.651