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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1cdo NAD Alcohol dehydrogenase 1 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 1.104
3uko NADAlcohol dehydrogenase class-3 / 0.818
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.789
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.785
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.785
2vhx NADAlanine dehydrogenase 1.4.1.1 0.783
4jji NADAlcohol dehydrogenase class-3 / 0.782
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.775
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.775
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.767
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.764
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.764
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.759
1qlh NADAlcohol dehydrogenase E chain 1.1.1.1 0.759
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.758
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.758
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.757
4gl4 NAIAlcohol dehydrogenase class-3 / 0.755
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.752
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.746
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.744
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.743
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.742
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.741
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.739
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.739
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.738
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.737
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.733
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.729
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.725
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.724
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.723
1e3e NAIAlcohol dehydrogenase 4 1.1.1.1 0.722
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.722
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.722
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.721
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.721
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.721
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.721
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.719
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.715
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.714
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.708
4l0q NADAlcohol dehydrogenase class-3 / 0.705
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.704
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.703
3x2f NAIAdenosylhomocysteinase / 0.703
2g5c NADPrephenate dehydrogenase / 0.701
1pjc NADAlanine dehydrogenase / 0.699
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.696
2voj NADAlanine dehydrogenase 1.4.1.1 0.695
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.694
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.693
4xq9 NADHomospermidine synthase 2.5.1.44 0.691
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.688
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.686
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.686
3jv7 NADSecondary alcohol dehydrogenase / 0.684
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.683
3abi NADUncharacterized protein / 0.682
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.681
3ikt NADRedox-sensing transcriptional repressor Rex / 0.680
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.679
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.677
4tvb NADHomospermidine synthase 2.5.1.44 0.676
4xqc NADHomospermidine synthase 2.5.1.44 0.676
4xrg NADHomospermidine synthase 2.5.1.44 0.674
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.673
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.673
1j49 NADD-lactate dehydrogenase 1.1.1.28 0.672
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.670
4rqu NADAlcohol dehydrogenase class-P / 0.669
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.667
2gr0 ADPFerredoxin reductase / 0.666
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.665
1uxj NADMalate dehydrogenase / 0.664
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.663
1vsv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.662
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.660
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.660
3oet NADErythronate-4-phosphate dehydrogenase / 0.659
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.659
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.658
2dph NADFormaldehyde dismutase / 0.657
1hku NADC-terminal-binding protein 1 1.1.1 0.656
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.656
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.656
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.654
3gvh NADMalate dehydrogenase / 0.654
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.653
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.653
1lso NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.652
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.652
1ur5 NADMalate dehydrogenase / 0.651
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.651
4cpd NADAlcohol dehydrogenase / 0.651
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.651
3wbf NAPMeso-diaminopimelate D-dehydrogenase / 0.650