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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1cd2 FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1cd2 FOLDihydrofolate reductase 1.5.1.3 1.033
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.861
4m6k FOLDihydrofolate reductase 1.5.1.3 0.847
1dyi FOLDihydrofolate reductase 1.5.1.3 0.821
1dyh DZFDihydrofolate reductase 1.5.1.3 0.819
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.812
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.803
4x5g FOLDihydrofolate reductase 1.5.1.3 0.803
2zza FOLDihydrofolate reductase / 0.802
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.796
4keb FOLDihydrofolate reductase 1.5.1.3 0.793
4x5h FOLDihydrofolate reductase 1.5.1.3 0.793
4x5f FOLDihydrofolate reductase 1.5.1.3 0.791
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.790
4kfj FOLDihydrofolate reductase 1.5.1.3 0.789
1hfp MOTDihydrofolate reductase 1.5.1.3 0.787
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.787
1dhf FOLDihydrofolate reductase 1.5.1.3 0.785
2d0k FOLDihydrofolate reductase 1.5.1.3 0.781
2w3m FOLDihydrofolate reductase 1.5.1.3 0.778
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.777
4kjj FOLDihydrofolate reductase 1.5.1.3 0.776
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.775
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.773
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.772
4x5i FOLDihydrofolate reductase 1.5.1.3 0.771
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.770
4i13 FOLDihydrofolate reductase 1.5.1.3 0.767
1hfr MOTDihydrofolate reductase 1.5.1.3 0.764
1drf FOLDihydrofolate reductase 1.5.1.3 0.760
5hi6 MTXDihydrofolate reductase / 0.760
4fhb FOLDihydrofolate reductase 1.5.1.3 0.751
1dre MTXDihydrofolate reductase 1.5.1.3 0.747
4i1n FOLDihydrofolate reductase 1.5.1.3 0.744
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.743
5ccc DDFDihydrofolate reductase 1.5.1.3 0.743
2drc MTXDihydrofolate reductase 1.5.1.3 0.737
3dau MTXDihydrofolate reductase 1.5.1.3 0.736
1hfq MOTDihydrofolate reductase 1.5.1.3 0.732
4p66 MTXDihydrofolate reductase / 0.732
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.721
4m6l 21VDihydrofolate reductase 1.5.1.3 0.720
1dra MTXDihydrofolate reductase 1.5.1.3 0.718
1u70 MTXDihydrofolate reductase 1.5.1.3 0.718
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.718
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.715
3tqb FOLDihydrofolate reductase / 0.715
1tdr MTXDihydrofolate reductase 1.5.1.3 0.713
3och 2MXDihydrofolate reductase 1.5.1.3 0.710
3eig MTXDihydrofolate reductase 1.5.1.3 0.708
1dyj DDFDihydrofolate reductase 1.5.1.3 0.706
4qi9 MTXDihydrofolate reductase / 0.702
1drb MTXDihydrofolate reductase 1.5.1.3 0.701
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.701
1jom FFODihydrofolate reductase 1.5.1.3 0.699
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.697
2qk8 MTXDihydrofolate reductase / 0.696
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.695
1df7 MTXDihydrofolate reductase 1.5.1.3 0.693
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.691
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.688
1e26 GPBDihydrofolate reductase 1.5.1.3 0.685
1ohj COPDihydrofolate reductase 1.5.1.3 0.685
3dfr MTXDihydrofolate reductase 1.5.1.3 0.685
7dfr FOLDihydrofolate reductase 1.5.1.3 0.682
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.681
1dhj MTXDihydrofolate reductase 1.5.1.3 0.680
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.678
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.678
3drc MTXDihydrofolate reductase 1.5.1.3 0.678
3dat MTXDihydrofolate reductase / 0.677
2dhf DZFDihydrofolate reductase 1.5.1.3 0.676
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.676
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.674
4dfr MTXDihydrofolate reductase 1.5.1.3 0.674
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.673
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.671
1re7 FOLDihydrofolate reductase 1.5.1.3 0.670
4p68 MTXDihydrofolate reductase / 0.668
1dhi MTXDihydrofolate reductase 1.5.1.3 0.666
4eil FOLBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.658
3ghv GHCDihydrofolate reductase 1.5.1.3 0.657
1n38 U3HRNA-directed RNA polymerase lambda-3 2.7.7.48 0.656
4x5j FOLDihydrofolate reductase 1.5.1.3 0.655
3k45 51PDihydrofolate reductase 1.5.1.3 0.653
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.651
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.651
3ia4 MTXDihydrofolate reductase / 0.650
4ixf IXFDihydrofolate reductase 1.5.1.3 0.650