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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1c3x 8IG Purine nucleoside phosphorylase 2.4.2.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1c3x 8IGPurine nucleoside phosphorylase 2.4.2.1 0.721
1h7u AGSMismatch repair endonuclease PMS2 3.1 0.661
3blq ATPCyclin-dependent kinase 9 2.7.11.22 0.661
4fnc HMUG/T mismatch-specific thymine DNA glycosylase 3.2.2.29 0.661
1dgm ADNAdenosine kinase 2.7.1.20 0.660
1n35 CH1RNA-directed RNA polymerase lambda-3 2.7.7.48 0.660
1o51 ADPUPF0166 protein TM_0021 / 0.660
1onp FOM1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.660
1r8c UTPCCA-adding enzyme 2.7.7.72 0.660
1u26 IHSMyo-inositol hexaphosphate phosphohydrolase / 0.660
1wet GUNHTH-type transcriptional repressor PurR / 0.660
1xxj UNCUricase 1.7.3.3 0.660
1ybu APCProbable lignin peroxidase LipJ / 0.660
1yf8 P6CBeta-galactoside-specific lectin 4 3.2.2.22 0.660
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.660
2d09 FLVBiflaviolin synthase CYP158A2 / 0.660
2e91 ZOLGeranylgeranyl pyrophosphate synthase / 0.660
2fzk CTPAspartate carbamoyltransferase regulatory chain / 0.660
2jjx ATPUridylate kinase / 0.660
2oap ANPType II secretion system protein (GspE-2) / 0.660
2qf2 GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.660
2vd7 PD2Lysine-specific demethylase 4A 1.14.11 0.660
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.660
2zev IPEGeranylgeranyl pyrophosphate synthase / 0.660
2zfi ADPKinesin-like protein KIF1A / 0.660
2zsa ADPPantothenate kinase 2.7.1.33 0.660
2zsb ADPPantothenate kinase 2.7.1.33 0.660
3af3 GCPPantothenate kinase 2.7.1.33 0.660
3af4 GCPPantothenate kinase 2.7.1.33 0.660
3ar5 TM1Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 3.6.3.8 0.660
3au2 DGTDNA polymerase beta family (X family) / 0.660
3cob ADPKinesin heavy chain-like protein / 0.660
3f8p NADNADH oxidase/thioredoxin reductase / 0.660
3fzf ATPHeat shock cognate 71 kDa protein / 0.660
3l1c ADPProtein claret segregational / 0.660
3lm9 ADPPutative fructokinase 2.7.1.4 0.660
3ppo DCKGlycine betaine/carnitine/choline-binding protein OpuCC / 0.660
3rkr NAPUncharacterized protein / 0.660
3ta2 ATPNitrogen regulatory protein P-II (GlnB-3) / 0.660
3u9d ATPActin, alpha skeletal muscle / 0.660
3w6h AZMCarbonic anhydrase 1 4.2.1.1 0.660
3ypi PGHTriosephosphate isomerase 5.3.1.1 0.660
3zcb ATPAdenosine monophosphate-protein transferase VbhT 2.7.7.n1 0.660
3zzn ADPL-lactate dehydrogenase / 0.660
4a8m GTPRNA-directed RNA polymerase 2.7.7.48 0.660
4at8 ATPInterleukin enhancer-binding factor 2 / 0.660
4blt APCNTPase P4 / 0.660
4cei ANPATP-dependent helicase/deoxyribonuclease subunit B 3.1 0.660
4cvl ACPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase / 0.660
4diq PD2Ribosomal oxygenase 1 / 0.660
4e09 ACPPlasmid partitioning protein ParF / 0.660
4e5l DBHPolymerase acidic protein / 0.660
4fdu IHSPutative multiple inositol polyphosphate histidine phosphatase 1 / 0.660
4hdh ATPGenome polyprotein 2.7.7.48 0.660
4ie5 MD6Alpha-ketoglutarate-dependent dioxygenase FTO / 0.660
4k6r ATPBifunctional protein GlmU / 0.660
4uz6 SCRPalmitoleoyl-protein carboxylesterase NOTUM / 0.660
5egh PCEctonucleotide pyrophosphatase/phosphodiesterase family member 6 / 0.660
5eso ISC2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.660
5i67 GDPPhosphoenolpyruvate carboxykinase [GTP] / 0.657
2pmi AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.655
4co0 ADPNitrogen regulatory protein P-II 1 / 0.654
1ad5 ANPTyrosine-protein kinase HCK 2.7.10.2 0.653
3c4x ATPRhodopsin kinase / 0.652