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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1bpj UMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1bpj UMPThymidylate synthase / 0.968
1bp0 UMPThymidylate synthase / 0.806
1tsy UMPThymidylate synthase / 0.782
1njd UMPThymidylate synthase / 0.767
1bp6 UMPThymidylate synthase / 0.761
2tdm UMPThymidylate synthase / 0.754
1jmh UMPThymidylate synthase / 0.746
1tsx UMPThymidylate synthase / 0.746
1vzb UMPThymidylate synthase / 0.745
1jmi UMPThymidylate synthase / 0.741
1tsv UMPThymidylate synthase / 0.739
1nja DCMThymidylate synthase / 0.725
1bid UMPThymidylate synthase / 0.720
1njc DCMThymidylate synthase / 0.720
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.719
2g86 UMPThymidylate synthase / 0.713
4eb4 UMPThymidylate synthase 2.1.1.45 0.713
1nje DCMThymidylate synthase / 0.712
3bgx TMPThymidylate synthase / 0.712
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.712
2g89 UMPThymidylate synthase / 0.711
1jmg UMPThymidylate synthase / 0.706
2vet UMPThymidylate synthase / 0.704
4e5o UMPThymidylate synthase 2.1.1.45 0.701
4isk UMPThymidylate synthase / 0.701
1bdu DURThymidylate synthase / 0.699
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.697
1ddu DDUThymidylate synthase / 0.695
4ein NOHThymidylate synthase 2.1.1.45 0.695
1f28 UMPThymidylate synthase 2.1.1.45 0.689
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.689
1njb UMPThymidylate synthase / 0.689
1vza UMPThymidylate synthase / 0.680
1jmf UMPThymidylate synthase / 0.678
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.678
4iqq UMPThymidylate synthase / 0.677
5by6 UMPThymidylate synthase / 0.666
1tdc UMPThymidylate synthase / 0.665
1tdu DURThymidylate synthase / 0.663
4fox UMPThymidylate synthase ThyA / 0.660
2g8a UMPThymidylate synthase / 0.653
4psg NOHThymidylate synthase / 0.652
1aob DDUThymidylate synthase / 0.650
2g8d UMPThymidylate synthase / 0.650