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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1bp0 UMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1bp0 UMPThymidylate synthase / 0.977
1tsy UMPThymidylate synthase / 0.928
1vzb UMPThymidylate synthase / 0.888
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.869
1njd UMPThymidylate synthase / 0.859
2tdm UMPThymidylate synthase / 0.858
1njc DCMThymidylate synthase / 0.826
1f28 UMPThymidylate synthase 2.1.1.45 0.814
1jmi UMPThymidylate synthase / 0.813
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.810
1jmh UMPThymidylate synthase / 0.809
1bp6 UMPThymidylate synthase / 0.807
1bpj UMPThymidylate synthase / 0.806
1tsv UMPThymidylate synthase / 0.804
2g86 UMPThymidylate synthase / 0.796
2g8a UMPThymidylate synthase / 0.796
1bid UMPThymidylate synthase / 0.792
2g89 UMPThymidylate synthase / 0.782
5by6 UMPThymidylate synthase / 0.778
1nje DCMThymidylate synthase / 0.775
1tys TMPThymidylate synthase / 0.773
4e5o UMPThymidylate synthase 2.1.1.45 0.772
3bgx TMPThymidylate synthase / 0.770
1jmg UMPThymidylate synthase / 0.768
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.767
1nja DCMThymidylate synthase / 0.767
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.766
4ein NOHThymidylate synthase 2.1.1.45 0.766
1njb UMPThymidylate synthase / 0.765
2fto TMPThymidylate synthase / 0.764
1vza UMPThymidylate synthase / 0.762
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.760
4dq1 UMPThymidylate synthase / 0.760
2vet UMPThymidylate synthase / 0.750
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.750
4eb4 UMPThymidylate synthase 2.1.1.45 0.747
1jmf UMPThymidylate synthase / 0.739
2g8d UMPThymidylate synthase / 0.736
4isk UMPThymidylate synthase / 0.732
1ddu DDUThymidylate synthase / 0.725
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.722
1bdu DURThymidylate synthase / 0.700
3qj7 UMPThymidylate synthase ThyA / 0.697
4fox UMPThymidylate synthase ThyA / 0.696
4iqq UMPThymidylate synthase / 0.694
1tsx UMPThymidylate synthase / 0.693
1tdu DURThymidylate synthase / 0.687
4irr UMPThymidylate synthase / 0.682
4psg NOHThymidylate synthase / 0.679
1aob DDUThymidylate synthase / 0.676
4h0u UMPThymidylate synthase / 0.669
3acy 702Dehydrosqualene synthase / 0.656
2tsr UMPThymidylate synthase 2.1.1.45 0.651