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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1bil 0IU Renin 3.4.23.15

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1bil 0IURenin 3.4.23.15 1.398
2g20 L1ARenin 3.4.23.15 0.926
1bim 0QBRenin 3.4.23.15 0.920
1od1 0QSEndothiapepsin 3.4.23.22 0.779
1rne C60Renin 3.4.23.15 0.768
2jjj 0QSEndothiapepsin 3.4.23.22 0.768
1e80 0GQEndothiapepsin 3.4.23.22 0.765
3own 3OXRenin 3.4.23.15 0.734
2g94 ZPQBeta-secretase 1 3.4.23.46 0.730
1eag A70Candidapepsin-2 3.4.23.24 0.725
1gvt 2ZSEndothiapepsin 3.4.23.22 0.724
2jji 0QSEndothiapepsin 3.4.23.22 0.717
3own 3OWRenin 3.4.23.15 0.702
3ixj 586Beta-secretase 1 3.4.23.46 0.691
3k5f AYHBeta-secretase 1 3.4.23.46 0.691
2vie VG0Beta-secretase 1 3.4.23.46 0.689
3dv1 AR9Beta-secretase 1 3.4.23.46 0.686
1ppl 1Z7Penicillopepsin-1 3.4.23.20 0.681
2p8h MY9Beta-secretase 1 3.4.23.46 0.681
4exg 916Beta-secretase 1 3.4.23.46 0.677
2fdp FRPBeta-secretase 1 3.4.23.46 0.670
2iqg F2IBeta-secretase 1 3.4.23.46 0.670
2p4j 23IBeta-secretase 1 3.4.23.46 0.664
1ppk IVVPenicillopepsin-1 3.4.23.20 0.663
3qi1 C6ABeta-secretase 1 3.4.23.46 0.662
3qp6 HL6Transcriptional activator, LuxR/UhpA family of regulators / 0.662
3i25 MV7Beta-secretase 1 3.4.23.46 0.658
3k5d XLIBeta-secretase 1 3.4.23.46 0.657
4ke0 1R8Beta-secretase 1 3.4.23.46 0.654