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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1b38 ATP Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1b38 ATPCyclin-dependent kinase 2 2.7.11.22 1.132
1hck ATPCyclin-dependent kinase 2 2.7.11.22 0.949
4m69 ANPReceptor-interacting serine/threonine-protein kinase 3 2.7.11.1 0.836
1b39 ATPCyclin-dependent kinase 2 2.7.11.22 0.822
4zse ANPEpidermal growth factor receptor 2.7.10.1 0.812
3lmg ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.806
4lv5 ADPRhoptry protein 5B / 0.733
3q60 ATPRhoptry protein 5B / 0.722
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.712
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.711
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.698
3kmw ATPIntegrin-linked protein kinase 2.7.11.1 0.693
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.693
1n2g APCPantothenate synthetase 6.3.2.1 0.686
3rep ATPIntegrin-linked protein kinase 2.7.11.1 0.683
4col DTPUncharacterized protein / 0.681
4h3p ANPMitogen-activated protein kinase 1 2.7.11.24 0.681
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.681
3sl2 ATPSensor histidine kinase WalK / 0.678
1n75 ATPGlutamate--tRNA ligase 6.1.1.17 0.675
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.673
4gqk ADPActin cross-linking toxin VgrG1 / 0.670
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.670
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.669
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.668
3t1k ANPHeat shock protein HSP 90-alpha / 0.664
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.661
2w5a ADPSerine/threonine-protein kinase Nek2 2.7.11.1 0.660
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.660
1e1v CMGCyclin-dependent kinase 2 2.7.11.22 0.658
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.656
1vi2 NADQuinate/shikimate dehydrogenase / 0.656
4aw0 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.656
3ork AGSSerine/threonine protein kinase / 0.655
3ort AGSSerine/threonine protein kinase / 0.655
4riy ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.655
1f3l SAHProtein arginine N-methyltransferase 3 / 0.654
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.654
4r6x SAHPhosphoethanolamine N-methyltransferase / 0.652
4wuc ANPDNA gyrase subunit B / 0.652
3ruq ADPChaperonin / 0.651
4lv8 ADPRhoptry protein 5 C / 0.651
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.650
4dxj 0M9Farnesyl pyrophosphate synthase / 0.650
5je2 SAHMethyl transferase / 0.650