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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1b15 NAE Alcohol dehydrogenase 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1b15 NAEAlcohol dehydrogenase 1.1.1.1 1.314
1b16 NAQAlcohol dehydrogenase 1.1.1.1 1.198
3rj5 NADAlcohol dehydrogenase 1.1.1.1 1.100
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 1.073
1b2l NDCAlcohol dehydrogenase 1.1.1.1 1.024
3rj9 NADAlcohol dehydrogenase 1.1.1.1 1.024
1sby NADAlcohol dehydrogenase 1.1.1.1 0.872
1b14 NADAlcohol dehydrogenase 1.1.1.1 0.836
1u7t TDT3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.832
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.810
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.797
2p5y NADUDP-glucose 4-epimerase / 0.796
4o0l NDPNADPH-dependent 3-quinuclidinone reductase / 0.790
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.782
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.780
2wsb NADGalactitol dehydrogenase / 0.779
3wds NADNADH-dependent quinuclidinone reductase / 0.776
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.775
3p19 NDPPutative blue fluorescent protein / 0.774
4fj0 NAP17beta-hydroxysteroid dehydrogenase / 0.774
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.773
4nbu NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.767
4qec NAPElxO / 0.767
1x7g NAPPutative ketoacyl reductase 1.3.1 0.763
3tsc NADUncharacterized protein / 0.762
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.760
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.760
4kwh NAPReductase homolog / 0.759
3aut NAIGlucose 1-dehydrogenase 4 1.1.1.47 0.757
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.755
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.754
4b79 NADProbable short-chain dehydrogenase / 0.750
4fj2 NAP17beta-hydroxysteroid dehydrogenase / 0.748
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.747
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.747
4yag NAIC alpha-dehydrogenase / 0.747
1w4z NAPPutative ketoacyl reductase 1.3.1 0.743
4k6f NAPPutative Acetoacetyl-CoA reductase / 0.743
1edo NAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic 1.1.1.100 0.741
2aqh NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.740
1g0n NDPTetrahydroxynaphthalene reductase 1.1.1.252 0.739
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.739
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.739
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.739
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.738
4dre NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.738
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.735
1x7h NDPPutative ketoacyl reductase 1.3.1 0.733
2ntj P1HEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.733
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.730
3ak4 NADNADH-dependent quinuclidinone reductase / 0.729
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 0.729
2c29 NAPDihydroflavonol 4-reductase / 0.728
2dte NAIGlucose 1-dehydrogenase related protein / 0.727
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.727
1nfr NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.726
2zat NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.726
3o26 NDPSalutaridine reductase / 0.725
1ae1 NAPTropinone reductase 1 / 0.724
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.723
1oaa NAPSepiapterin reductase 1.1.1.153 0.723
3mje NDPAmphB / 0.723
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.721
3ruf NADUDP-N-acetylglucosamine 4-epimerase / 0.721
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.721
1zem NADXylitol dehydrogenase / 0.720
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.720
1nff NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.719
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.718
2wdz NADGalactitol dehydrogenase / 0.716
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.714
4i5e NAPAlclohol dehydrogenase/short-chain dehydrogenase / 0.713
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.712
4yai NAIC alpha-dehydrogenase / 0.712
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.711
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.709
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.709
2ekp NAD2-deoxy-D-gluconate 3-dehydrogenase / 0.709
3geg NADShort-chain dehydrogenase/reductase SDR / 0.708
3sju NDPKeto reductase / 0.708
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.707
1sny NAPLD36273p / 0.706
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.705
3o4r NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.704
2aqk NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.703
2aq8 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.701
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.701
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.701
4qed NAPElxO / 0.701
3qwf NAP17beta-hydroxysteroid dehydrogenase / 0.700
2bgm NAJSecoisolariciresinol dehydrogenase 1.1.1.331 0.699
3ndr NADPyridoxal 4-dehydrogenase 1.1.1.107 0.699
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.698
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.697
4dbz NDPPutative ketoacyl reductase 1.3.1 0.697
5d2e NAPMlnE / 0.696
1g6k NADGlucose 1-dehydrogenase 1.1.1.47 0.692
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.692
1ipe NDPTropinone reductase 2 1.1.1.236 0.691
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.691
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.691
3l77 NJPShort-chain alcohol dehydrogenase / 0.691
1fk8 NAD3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase 1.1.1.50 0.690
1h5q NAPNADP-dependent mannitol dehydrogenase 1.1.1.138 0.690
3rud NADUDP-N-acetylglucosamine 4-epimerase / 0.690
3ruh NADUDP-N-acetylglucosamine 4-epimerase / 0.690
2b37 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.689
2nv6 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.689
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.689
3sj7 NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative / 0.689
2ag5 NAD3-hydroxybutyrate dehydrogenase type 2 / 0.688
3ai3 NDPNADPH-sorbose reductase / 0.688
2bd0 NAPSepiapterin reductase / 0.687
4dmm NAP3-oxoacyl-[acyl-carrier-protein] reductase / 0.687
4wec NADShort chain dehydrogenase / 0.687
4cql NADEstradiol 17-beta-dehydrogenase 8 1.1.1.62 0.686
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.685
3qrw NDPPutative ketoacyl reductase 1.3.1 0.685
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.685
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.684
4iqg NAPShort-chain dehydrogenase/reductase SDR / 0.684
4u7w NDPMxaA / 0.684
3rue NADUDP-N-acetylglucosamine 4-epimerase / 0.682
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.681
3uce NDPDehydrogenase / 0.681
3icp NADNAD-dependent epimerase/dehydratase / 0.680
4hwk NAPSepiapterin reductase 1.1.1.153 0.680
2p5u NADUDP-glucose 4-epimerase / 0.679
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.679
3ru7 NADUDP-N-acetylglucosamine 4-epimerase / 0.679
3gy0 NAPNAD(P)-dependent oxidoreductase / 0.677
4idg NADPutative UDP-glucose 4-epimerase / 0.677
2z1m NDPGDP-mannose 4,6-dehydratase / 0.676
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.674
2yut NAPPutative short-chain oxidoreductase / 0.674
4bmv NAPShort-chain dehydrogenase / 0.674
4clo NAPPteridine reductase / 0.674
4j7x NAPSepiapterin reductase 1.1.1.153 0.674
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.674
3rua NADUDP-N-acetylglucosamine 4-epimerase / 0.673
2ieb ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.672
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.672
3tox NAPPutative oxidoreductase / 0.672
2pk3 A2RGDP-6-deoxy-D-mannose reductase / 0.671
1n7h NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.670
2nq8 ZIDEnoyl-ACP reductase / 0.670
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.670
3o03 NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) / 0.669
3oey NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.669
2b69 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.668
2c54 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.668
3a4v NADNDP-sugar epimerase / 0.668
2q2q NADBeta-D-hydroxybutyrate dehydrogenase / 0.667
1i3l NADUDP-glucose 4-epimerase / 0.664
1qyv NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.662
2idz ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.661
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.661
3zu2 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.661
5lc1 NADL-threonine 3-dehydrogenase / 0.661
3ajr NADNDP-sugar epimerase / 0.660
3h4v NAPPteridine reductase 1 1.5.1.33 0.660
1pr9 NAPL-xylulose reductase 1.1.1.10 0.659
3uxy NADShort-chain dehydrogenase/reductase SDR / 0.659
4fn4 NADShort chain dehydrogenase / 0.659
4bii NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.658
4c7k NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.658
1g1a NADdTDP-glucose 4,6-dehydratase / 0.656
2b35 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.656
2b4q NAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.656
2ie0 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.656
3ai2 NDPNADPH-sorbose reductase / 0.656
4dqu NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.656
1eq2 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.655
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.655
5jyd NADShort chain dehydrogenase / 0.655
4trn NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.652
2ntv P1HEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.650
4fc7 NAPPeroxisomal 2,4-dienoyl-CoA reductase 1.3.1.34 0.650
4hxy NDPPlm1 / 0.650