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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1arg PPD Aspartate aminotransferase 2.6.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1arg PPDAspartate aminotransferase 2.6.1.1 1.347
1cq7 PY5Aspartate aminotransferase 2.6.1.1 1.140
1cq8 PY6Aspartate aminotransferase 2.6.1.1 1.122
1arh PPDAspartate aminotransferase 2.6.1.1 1.119
1x28 PGUAspartate aminotransferase 2.6.1.1 1.069
1ahg TYR_PLPAspartate aminotransferase 2.6.1.1 1.036
1akc PPEAspartate aminotransferase, mitochondrial 2.6.1.1 0.989
1maq PGUAspartate aminotransferase, mitochondrial 2.6.1.1 0.931
3qpg 3QPAspartate aminotransferase 2.6.1.1 0.901
1ivr CBAAspartate aminotransferase, mitochondrial 2.6.1.1 0.890
1akb PPDAspartate aminotransferase, mitochondrial 2.6.1.1 0.872
4dbc 3QPAspartate aminotransferase 2.6.1.1 0.871
1cq6 PY4Aspartate aminotransferase 2.6.1.1 0.852
1map KETAspartate aminotransferase, mitochondrial 2.6.1.1 0.843
4w5k PLPAspartate aminotransferase, mitochondrial / 0.826
4ge4 0KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.769
4geb 0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.766
1cl2 PPGCystathionine beta-lyase MetC 4.4.1.8 0.764
4emy PLPAminotransferase class I and II / 0.757
4itx IN5Cystathionine beta-lyase MetC 4.4.1.8 0.757
1aka PLPAspartate aminotransferase, mitochondrial 2.6.1.1 0.756
3aej AA5Methionine gamma-lyase / 0.736
1u08 PLPMethionine aminotransferase / 0.702
3ele PLPAminotransferase / 0.683
3vax PLPUncharacterized protein / 0.679
4wxg 2BOSerine hydroxymethyltransferase / 0.675
4d96 5PAD-cysteine desulfhydrase / 0.673
1wkh PPE[LysW]-aminoadipate semialdehyde transaminase / 0.672
4rkd KETAminotransferase / 0.670
4bqy FNTEgl nine homolog 1 / 0.666
3ei8 PL5LL-diaminopimelate aminotransferase, chloroplastic / 0.664
4je5 PLPAromatic/aminoadipate aminotransferase 1 2.6.1.39 0.664
1dfo PLGSerine hydroxymethyltransferase 2.1.2.1 0.663
2vbp VB1Isopenicillin N synthase 1.21.3.1 0.662
4ge9 0L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.662
4wlj IK2Kynurenine--oxoglutarate transaminase 1 2.6.1.7 0.662
2ay2 CXPAromatic-amino-acid aminotransferase 2.6.1.57 0.661
4gdy 0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.661
3cl2 G39Neuraminidase / 0.660
1w06 W05Isopenicillin N synthase 1.21.3.1 0.658
4aoa IK2Beta-phenylalanine transaminase 2.6.1 0.658
1qiq ACCIsopenicillin N synthase 1.21.3.1 0.657
2fq6 P3FCystathionine beta-lyase MetC 4.4.1.8 0.657
4wxf PLGSerine hydroxymethyltransferase / 0.654
5k8b PDG8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase / 0.653
4ge7 0K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.651