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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1aka PLP Aspartate aminotransferase, mitochondrial 2.6.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1aka PLPAspartate aminotransferase, mitochondrial 2.6.1.1 1.065
1akb PPDAspartate aminotransferase, mitochondrial 2.6.1.1 0.867
1ivr CBAAspartate aminotransferase, mitochondrial 2.6.1.1 0.841
1akc PPEAspartate aminotransferase, mitochondrial 2.6.1.1 0.838
1cq6 PY4Aspartate aminotransferase 2.6.1.1 0.780
1oxo IK2Aspartate aminotransferase, mitochondrial 2.6.1.1 0.758
1arg PPDAspartate aminotransferase 2.6.1.1 0.756
4ge7 0K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.740
1maq PGUAspartate aminotransferase, mitochondrial 2.6.1.1 0.731
3ele PLPAminotransferase / 0.714
1arh PPDAspartate aminotransferase 2.6.1.1 0.713
3qpg 3QPAspartate aminotransferase 2.6.1.1 0.705
4geb 0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.703
1map KETAspartate aminotransferase, mitochondrial 2.6.1.1 0.698
4dbc 3QPAspartate aminotransferase 2.6.1.1 0.697
4gdy 0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.694
1cq8 PY6Aspartate aminotransferase 2.6.1.1 0.682
1cq7 PY5Aspartate aminotransferase 2.6.1.1 0.681
1x28 PGUAspartate aminotransferase 2.6.1.1 0.681
4ge9 0L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.673
4emy PLPAminotransferase class I and II / 0.662
4je5 PLPAromatic/aminoadipate aminotransferase 1 2.6.1.39 0.656
1ahg TYR_PLPAspartate aminotransferase 2.6.1.1 0.654
3h03 UBPGlutamate receptor 2 / 0.653