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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1aj2 2PH Dihydropteroate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1aj2 2PHDihydropteroate synthase / 1.030
1tww HH2Dihydropteroate synthase / 0.760
2dzb HH2Dihydropteroate synthase / 0.706
3h24 B55Dihydropteroate synthase / 0.687
2bmb PMMFolic acid synthesis protein FOL1 / 0.685
1e1m NAPNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.677
3h2n B62Dihydropteroate synthase / 0.672
3m0e ATPTranscriptional regulator (NtrC family) / 0.672
3tyc XHPDihydropteroate synthase / 0.672
2y5s 78HDihydropteroate synthase / 0.668
3tr9 PT1Dihydropteroate synthase / 0.664
4ttb FMNIodotyrosine deiodinase 1 / 0.664
3tye XTZDihydropteroate synthase / 0.661
1yki FMNOxygen-insensitive NAD(P)H nitroreductase / 0.660
1ipe NDPTropinone reductase 2 1.1.1.236 0.657
3to0 FMNIodotyrosine deiodinase 1 1.21.1.1 0.657
4eb4 UMPThymidylate synthase 2.1.1.45 0.655
4i5e NAPAlclohol dehydrogenase/short-chain dehydrogenase / 0.655
2cvy TTPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.654
4e5o UMPThymidylate synthase 2.1.1.45 0.652
2hw1 ANPKetohexokinase / 0.651
4kyh ZSTLactoylglutathione lyase 4.4.1.5 0.650