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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1adb CND Alcohol dehydrogenase E chain 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 1.233
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.999
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.993
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.990
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.987
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.986
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.986
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.979
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.976
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.973
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.971
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.962
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.943
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.942
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.932
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.931
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.926
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.921
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.913
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.906
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.902
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.901
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.899
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.898
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.895
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.893
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.892
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.887
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.878
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.873
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.870
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.856
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.844
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.841
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.825
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.820
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.820
3jv7 NADSecondary alcohol dehydrogenase / 0.819
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.817
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.816
4oaq NDPR-specific carbonyl reductase / 0.800
1yqd NAPSinapyl alcohol dehydrogenase / 0.799
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.798
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.790
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.783
3wle NAD(R)-specific carbonyl reductase / 0.775
4c4o NADSADH / 0.766
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.756
3two NDPMannitol dehydrogenase / 0.755
2xaa NADSecondary alcohol dehydrogenase / 0.754
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.754
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.748
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.745
1uxk NADMalate dehydrogenase / 0.740
1uxj NADMalate dehydrogenase / 0.735
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.732
2dph NADFormaldehyde dismutase / 0.731
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.731
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.730
4jji NADAlcohol dehydrogenase class-3 / 0.730
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.727
1yqx NAPSinapyl alcohol dehydrogenase / 0.726
3uko NADAlcohol dehydrogenase class-3 / 0.724
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.722
4rqu NADAlcohol dehydrogenase class-P / 0.716
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.707
4cpd NADAlcohol dehydrogenase / 0.707
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.704
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.703
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.703
2voj NADAlanine dehydrogenase 1.4.1.1 0.701
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.701
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.695
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.692
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.692
3ggp NADPrephenate dehydrogenase / 0.684
5a1t NAIL-lactate dehydrogenase / 0.684
4l0q NADAlcohol dehydrogenase class-3 / 0.682
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.680
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.679
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.677
4gl4 NAIAlcohol dehydrogenase class-3 / 0.674
1guy NADMalate dehydrogenase / 0.672
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.671
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.671
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.669
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.668
1ur5 NADMalate dehydrogenase / 0.666
4ejm NAPPutative zinc-binding dehydrogenase / 0.666
1llu NADAlcohol dehydrogenase / 0.664
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.663
1pzh NADLactate dehydrogenase / 0.662
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.662
1obb NADAlpha-glucosidase 3.2.1.20 0.660
1up7 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.660
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.660
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.659
5a04 NDPGlucose-fructose oxidoreductase / 0.659
1u7h NADPutative ornithine cyclodeaminase / 0.658
1x7d NADPutative ornithine cyclodeaminase / 0.657
2cda NAPGlucose 1-dehydrogenase / 0.657
5a02 NAPGlucose-fructose oxidoreductase / 0.657
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.656
1f8f NADBenzyl alcohol dehydrogenase / 0.655
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.655
3f3s NADLambda-crystallin homolog / 0.655
4jk3 NADUncharacterized protein / 0.654
1pj2 NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.652
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.652
3wbf NAPMeso-diaminopimelate D-dehydrogenase / 0.652
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.652
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.650