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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1a5u ATP Pyruvate kinase PKM 2.7.1.40

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1a5u ATPPyruvate kinase PKM 2.7.1.40 1.028
1ytm ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.679
4fxf ATPPyruvate kinase PKM 2.7.1.40 0.673
2z4z SC0Geranylgeranyl pyrophosphate synthase / 0.669
3rbm B73Farnesyl pyrophosphate synthase, putative / 0.669
2olq ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.664
4h5e YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.663
1jsz NDMCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2.1.1.57 0.660
4h5d YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.656
5i4n ATPTyrosine-protein kinase JAK2 / 0.655
2py7 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.652
1sxj AGSReplication factor C subunit 1 / 0.651
4dxj 0M9Farnesyl pyrophosphate synthase / 0.651
1khe GCPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.650